{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:41:33Z","timestamp":1776494493654,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although persons with hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection may experience nonhepatic illnesses, little is known about the frequency of and trends in such conditions in a population\u2010based sample of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected persons. Using hospitalization data collected during 2004\u20132011 from the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project, we examined trends in comorbidities among all hospitalizations that included either a principal or secondary <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> diagnostic code (i.e., <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> was not necessarily the cause for hospitalization). We also compared comorbidities among all persons aged 45\u201364\u00a0years hospitalized with and without principal or secondary <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> diagnostic codes. The estimated number of hospitalizations among persons with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection increased from 850\u00a0490 in 2004\u20132005 to 1\u00a0178\u00a0633 in 2010\u20132011; mean age at hospitalization was 50\u00a0years in 2004\u20132005 and 52.5\u00a0years in 2010\u20132011. There were significant increases in the prevalence of most medical and psychiatric comorbidities; the largest were for lipid disorders, chronic kidney disease and obesity. Among <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected aged 45\u201364 persons hospitalized for any cause, the prevalence of alcohol \/substance abuse, mental disorders, chronic kidney disease, pneumonia, hepatitis B virus infection and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection were significantly higher than those aged 45\u201364 persons hospitalized without <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for all). The prevalence of cryoglobulinaemia, vasculitis, nephrotic syndrome or membranoproliferative glomerulonephritis and porphyria cutanea tarda among hospitalizations with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection was consistently low during the study period (i.e., &lt;0.5%). The increase we observed in nonhepatic comorbidities associated with a high risk of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related complications has important implications for the current <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment recommendations in a greatly expanded treatment population.<\/jats:p>","DOI":"10.1111\/jvh.12414","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T09:47:32Z","timestamp":1429523252000},"page":"906-913","source":"Crossref","is-referenced-by-count":29,"title":["Increase in nonhepatic diagnoses among persons with hepatitis C hospitalized for any cause, United States, 2004\u20132011"],"prefix":"10.1111","volume":"22","author":[{"given":"X.","family":"Tong","sequence":"first","affiliation":[{"name":"Division of Viral Hepatitis Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"Spradling","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1133"},{"key":"e_1_2_11_3_1","volume-title":"Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C","author":"IOM (Institute of Medicine)","year":"2010"},{"key":"e_1_2_11_4_1","first-page":"615","article-title":"Hepatitis C: a multifaceted disease","volume":"123","author":"Gumber SC","year":"1995","journal-title":"N Engl J Med"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.08.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02235.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-86"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4993"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02458.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100790"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22703"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26892"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23562"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00885.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu077"},{"key":"e_1_2_11_16_1","unstructured":"American Association for the Study of Liver Diseases\/Infectious Disease Society of America. Recommendations for testing managing and treating hepatitis C.http:\/\/hcvguidelines.org\/full-report-view.AccessedAugust 1 2014."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v10n0501"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S53557"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2014.0096"},{"key":"e_1_2_11_20_1","unstructured":"Agency for Healthcare Research and Quality.Healthcare Cost and Utilization Project (HCUP).http:\/\/www.ahrq.gov\/research\/data\/hcup\/index.html. Accessed June 1 2014."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu427"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20941"},{"issue":"4","key":"e_1_2_11_23_1","first-page":"1","article-title":"Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945\u20101965","volume":"61","author":"CDC","year":"2012","journal-title":"MMWR"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214853"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402355"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.471"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:46:06Z","timestamp":1696261566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/jvh.12414"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12414","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]}}}