{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:34:20Z","timestamp":1778934860307,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DK00775716"],"award-info":[{"award-number":["T32DK00775716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection may cause kidney injury, particularly in the setting of cryoglobulinemia or cirrhosis; however, few studies have evaluated the epidemiology of acute kidney injury in patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. We aimed to describe national temporal trends of incidence and impact of severe acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) requiring renal replacement \u2018dialysis\u2010requiring <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\u2019 in hospitalized adults with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. We extracted our study cohort from the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project using data from 2004 to 2012. We defined <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and dialysis\u2010requiring acute kidney injury based on previously validated <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u20109\u2010<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> codes. We analysed temporal changes in the proportion of hospitalizations complicated by dialysis\u2010requiring <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> and utilized survey multivariable logistic regression models to estimate its impact on in\u2010hospital mortality. We identified a total of 4\u00a0603\u00a0718 adult hospitalizations with an associated diagnosis of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> from 2004 to 2012, of which 51\u00a0434 (1.12%) were complicated by dialysis\u2010requiring acute kidney injury. The proportion of hospitalizations complicated by dialysis\u2010requiring acute kidney injury increased significantly from 0.86% in 2004 to 1.28% in 2012. In\u2010hospital mortality was significantly higher in hospitalizations complicated by dialysis\u2010requiring acute kidney injury <jats:italic>vs<\/jats:italic> those without (27.38% <jats:italic>vs<\/jats:italic> 2.95%; adjusted odds ratio: 2.09; 95% confidence interval: 1.74\u20132.51). The proportion of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> hospitalizations complicated by dialysis\u2010requiring acute kidney injury increased significantly between 2004 and 2012. Similar to observations in the general population, dialysis\u2010requiring acute kidney injury was associated with a twofold increase in odds of in\u2010hospital mortality in adults with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. These results highlight the burden of acute kidney injury in hospitalized adults with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection.<\/jats:p>","DOI":"10.1111\/jvh.12437","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T06:17:28Z","timestamp":1437373048000},"page":"32-38","source":"Crossref","is-referenced-by-count":15,"title":["Dialysis\u2010requiring acute kidney injury among hospitalized adults with documented hepatitis C Virus infection: a nationwide inpatient sample analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"G. N.","family":"Nadkarni","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Public Health Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. K.","family":"Simoes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Luke's Roosevelt Hospital Center at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Yacoub","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Annapureddy","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kamat","sequence":"additional","affiliation":[{"name":"Division of Critical Care Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Perumalswami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Branch","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. G.","family":"Coca","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu427"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.12627"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283574e71"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00470107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2010.0104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.379"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1214243"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000220165.79736.d3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010073"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012080800"},{"key":"e_1_2_8_12_1","first-page":"19","article-title":"Use of the All Patient Refined\u2010Diagnosis Related Group (APR\u2010DRG) risk of mortality score as a severity adjustor in the medical ICU","volume":"2","author":"Baram D","year":"2008","journal-title":"Clin Med Circ Respir Pulm Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.293"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002297"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040245"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit373"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03572.x"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12437","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T19:55:50Z","timestamp":1692734150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,20]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jvh.12437"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12437","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,20]]}}}