{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:45:16Z","timestamp":1782308716401,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270532"],"award-info":[{"award-number":["81270532"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372094"],"award-info":[{"award-number":["81372094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300349"],"award-info":[{"award-number":["81300349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although endoplasmic reticulum (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) stress is critical in various liver diseases, its role in acute\u2010on\u2010chronic liver failure (Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content>) caused by acute exacerbation of chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) is still elusive. This study aimed to analyse <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress responses in the progression of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content>. Normal liver tissues (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), liver tissues of <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related patients with Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) were used. Electron microscopy of the ultrastructure of the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> was carried out on liver specimens. The gene and protein expression levels of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress\u2010related genes were measured. We further analysed the correlation between the expression levels of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress\u2010related molecules and liver injury. Electron microscopy identified typical features of the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> microstructure in Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content> subjects. Among the three pathways of unfolded protein responses, the <jats:styled-content style=\"fixed-case\">PKR<\/jats:styled-content>\u2010like <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> kinase and inositol\u2010requiring enzyme 1 signalling pathway were activated in <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> subjects and inactivated in Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content> subjects, while the activating transcription factor 6 signalling pathway was sustained in the activated form during the progression of Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content>; the expression of glucose\u2010regulated protein (Grp)78 and Grp94 was gradually decreased in Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content> subjects compared to healthy individuals and <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> subjects, showing a negative correlation with serum <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TBIL<\/jats:styled-content>; moreover, the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress\u2010related apoptosis molecules were activated in the progression of acute exacerbation of <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>. The dysregulated <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress response may play a complicated role in the pathogenesis of Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content>, and a severe <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress response may predict the occurrence of Ao<jats:styled-content style=\"fixed-case\">CLF<\/jats:styled-content> caused by acute exacerbation of <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.12438","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T11:39:21Z","timestamp":1438342761000},"page":"23-31","source":"Crossref","is-referenced-by-count":8,"title":["The dysregulation of endoplasmic reticulum stress response in acute\u2010on\u2010chronic liver failure patients caused by acute exacerbation of chronic hepatitis B"],"prefix":"10.1111","volume":"23","author":[{"given":"F.","family":"Ren","sequence":"first","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Wen","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Xie","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Municipal Laboratory for Liver Protection and Regulation of Regeneration Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Duan","sequence":"additional","affiliation":[{"name":"Beijing YouAn Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32835297ef"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(90)90069-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9106-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.10.1211"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2199"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2359"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151434"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v4.i1.10"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.12.7499"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/16729"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26373"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2004.09.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.06.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401840"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2755"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2703"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.10.039"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2006.09.011"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20102071"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.07.062"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034169"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991513"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.024"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2013.19.4.349"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216886"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T19:55:53Z","timestamp":1692734153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jvh.12438"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12438","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}