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Models were developed for 15 countries to quantify and characterize the viraemic population and forecast the changes in the infected population and the corresponding disease burden from 2014 to 2030. With the exception of Iceland, Iran, Latvia and Pakistan, the total number of viraemic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infections is expected to decline from 2014 to 2030, but the associated morbidity and mortality are expected to increase in all countries except for Japan and South Korea. In the latter two countries, mortality due to an ageing population will drive down prevalence, morbidity and mortality. On the other hand, both countries have already experienced a rapid increase in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality and morbidity. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related morbidity and mortality are projected to increase between 2014 and 2030 in all other countries as result of an ageing <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected population. Thus, although the total number of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> countries is expected to decline in most countries studied, the associated disease burden is expected to increase. The current treatment paradigm is inadequate if large reductions in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related morbidity and mortality are to be achieved.<\/jats:p>","DOI":"10.1111\/jvh.12476","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T19:47:01Z","timestamp":1446148021000},"page":"21-41","source":"Crossref","is-referenced-by-count":58,"title":["The present and future disease burden of hepatitis C virus infections with today's treatment paradigm \u2013 volume 3"],"prefix":"10.1111","volume":"22","author":[{"given":"A.","family":"Sibley","sequence":"first","affiliation":[{"name":"Center for Disease Analysis (CDA) Louisville CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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