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However, no data have been reported for the role of A20 in <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content>. This study aimed to investigate A20 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> and to determine the potential of A20 as a biomarker for the prognosis of <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content>. Quantitative real\u2010time polymerase chain reaction (<jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>) was used to measure the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of A20 in peripheral blood mononuclear cells (<jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>s) from 137 <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> patients, 105 chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) and 35 healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s). A secondary cohort with 37 <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> patients was set up as validation data set. The plasma levels of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101<jats:italic>\u03b2<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 were determined using enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). Receiver\u2010operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curves were used to determine the predictive value of A20 for the prognosis of <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> patients. A20 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> was significantly higher compared with <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s. In <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> patients, A20 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was closely associated with total bilirubin, albumin, international normalized ratio, prothrombin time activity and model for end\u2010stage liver disease. Furthermore, A20 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was significantly correlated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010. An optimal cut\u2010off value of 12.32 for A20 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> had significant power in discriminating survival or death in <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> patients. In conclusion, our results suggest that the up\u2010regulation of the A20 gene might contribute to the severity of <jats:styled-content style=\"fixed-case\">ACHBLF<\/jats:styled-content> and A20 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level might be a potential predictor for the prognosis of ACHBLF.<\/jats:p>","DOI":"10.1111\/jvh.12478","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T10:46:24Z","timestamp":1443091584000},"page":"180-190","source":"Crossref","is-referenced-by-count":7,"title":["Up\u2010regulation of A20 gene expression in peripheral blood mononuclear cells is associated with acute\u2010on\u2010chronic hepatitis B liver failure"],"prefix":"10.1111","volume":"23","author":[{"given":"Y.\u2010C.","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan China"},{"name":"Institute of Hepatology Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010Y.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Nephrology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan China"},{"name":"Institute of Hepatology Shandong University Jinan 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