{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:14:07Z","timestamp":1793060047697,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Hepatitis E is an inflammatory liver disease caused by infection with the hepatitis E virus (HEV). In tropical regions, HEV is highly endemic and predominantly mediated by HEV genotypes 1 and 2 with &gt;3 million symptomatic cases per year and around 70 000 deaths. In Europe and America, the zoonotic HEV genotypes 3 and 4 have been reported with continues increasing new infections per year. So far, little is known about T\u2010cell responses during acute HEV genotype 3 infection. Therefore, we did a comprehensive study investigating HEV\u2010specific T\u2010cell responses using genotypes 3\u2010 and 1\u2010specific overlapping peptides. Additional cytokines and chemokines were measured in the plasma. In four patients, longitudinal studies were performed. Broad functional HEV\u2010specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses were detectable in patients acutely infected with HEV genotype 3. Elevated of pro\u2010 and anti\u2010inflammatory cytokine levels during acute HEV infection correlated with ALT levels. Memory HEV\u2010specific T\u2010cell responses were detectable up to &gt;1.5 years upon infection. Importantly, cross\u2010genotype HEV\u2010specific T\u2010cell responses (between genotypes 1 and 3) were measurable in all investigated patients. In conclusion, we could show for the first time HEV\u2010specific T\u2010cell responses during and after acute HEV genotype 3 infection. Our data of cross\u2010genotype HEV\u2010specific T\u2010cell responses might suggest a potential role in cross\u2010genotype\u2010specific protection between HEV genotypes 1 and 3.\n                  <\/jats:p>","DOI":"10.1111\/jvh.12495","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T02:20:29Z","timestamp":1454898029000},"page":"305-315","source":"Crossref","is-referenced-by-count":39,"title":["Cross\u2010genotype\u2010specific T\u2010cell responses in acute hepatitis E virus (HEV) infection"],"prefix":"10.1111","volume":"23","author":[{"given":"A.","family":"Gisa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. V.","family":"Suneetha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Behrendt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pischke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"},{"name":"First Medical Center University Hospital Hamburg\u2010Eppendorf Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bremer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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