{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:51:40Z","timestamp":1764060700849},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI10\/02373"],"award-info":[{"award-number":["PI10\/02373"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The expression of activation\u2010induced cytidine deaminase, B\u2010aggressive lymphoma, cyclin D1 and serine\/threonine kinase 15 genes, among others, is increased in B cells from patients with chronic hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection. It is unknown whether the level of expression of these genes in B cells is increased in patients with hepatitis C who have achieved a sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) but who have persistent, detectable <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>, so\u2010called occult infection. Eighty\u2010three patients who achieved and <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>, 27 with detectable <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and 56 without detectable <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>, 28 chronic hepatitis C patients and 32 healthy controls were studied. <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was extracted from B cells, and gene expression levels were measured by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Patients with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and those who achieved an <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> (with and without persistent low\u2010level <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>) showed a statistically significant higher expression compared to healthy controls, of activation\u2010induced cytidine deaminase (<jats:italic>P<\/jats:italic> = 0.004, <jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> = 0.002, respectively), B\u2010aggressive lymphoma (<jats:italic>P<\/jats:italic> &lt; 0.001, <jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> = 0.006) and cyclin D1 (<jats:italic>P<\/jats:italic> = 0.026, <jats:italic>P<\/jats:italic> = 0.001; <jats:italic>P<\/jats:italic> = 0.038). For activation\u2010induced cytidine deaminase patients with an <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> and \u2018occult infection\u2019 had a statistically significantly higher expression level than patients with and <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> without \u2018occult infection\u2019 (<jats:italic>P<\/jats:italic> = 0.014). The higher expression levels found for activation\u2010induced cytidine deaminase, together with other genes indicates that these B lymphomagenesis\u2010related genes are upregulated following <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> therapy and this is more marked when <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> can be detected in <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/jvh.12526","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T07:36:56Z","timestamp":1457249816000},"page":"606-613","source":"Crossref","is-referenced-by-count":4,"title":["Lymphomagenesis\u2010related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection"],"prefix":"10.1111","volume":"23","author":[{"given":"M. C.","family":"Roque Cu\u00e9llar","sequence":"first","affiliation":[{"name":"Biomedicine Institute of Seville (IBIS) University Hospital Virgen del Rocio CSIC University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Garc\u00eda\u2010Lozano","sequence":"additional","affiliation":[{"name":"Department of Immunology IBIS University Hospital Virgen del Rocio CSIC University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Immunology IBIS University Hospital Virgen del Rocio CSIC University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Praena\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Statistics Methodology and Research Evaluation Unit Andalusian Public Foundation for Health Research Management in Seville (FISEVI) IBIS University Hospital Virgen del Rocio CSIC University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mart\u00ednez Sierra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Hospital Virgen del Rocio Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"N\u00fa\u00f1ez\u2010Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Immunology IBIS University Hospital Virgen del Rocio CSIC University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Aguilar\u2010Reina","sequence":"additional","affiliation":[{"name":"Biomedicine Institute of Seville (IBIS) University Hospital Virgen del Rocio CSIC University of Seville Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i23.2887"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22706"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21866"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(92)90073-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/980942"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.02.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4328"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0959"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1997.tb04519.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206297"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04311.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63177-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.35"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0303971101"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12320"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23345"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010511"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02750-06"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2008.01043.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01307-06"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00020.Wu"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1182\/blood.V96.13.4328","article-title":"BAL is a novel risk\u2010related gene in diffuse large B\u2010cell lymphomas that enhances cellular migration","volume":"96","author":"Aguiar RC","year":"2006","journal-title":"Blood"},{"key":"e_1_2_8_24_1","unstructured":"National Center for Biotechnology Information (NCBI).Gene database CCND1 cyclin D1 [Homo sapiens (human)] Gene ID: 595 (updated on 21 October 2014; cited 22 October 2014). 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