{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:53:05Z","timestamp":1790322785721,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Association de Recherche en Transfusion","award":["65-2013"],"award-info":[{"award-number":["65-2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Little is known about the natural history of Hepatitis E virus (<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>) infection in immunocompetent individuals. The prevalence, the course of infection and the occurrence of transmission by transfusion were investigated in multitransfused immunocompetent patients\/blood donor pairs included in a longitudinal sample repository collection and followed up between 1988 and 2010. Ninety\u2010eight subjects aged 6\u201389 years and suffering from acquired haemoglobinopathies were tested for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> markers (IgM, IgG and <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) in serial samples collected every 2 or 3 years. Eighteen patients (18.4%) were positive for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\u2010IgG at baseline with a prevalence increasing from 12.5% below 26 years to 32% above 56 years. Nine patients remained IgG positive along the study and nine lost their antibodies after a mean follow\u2010up of 7.4 years (1\u201322 years). One seropositive patient showed an increase of IgG level and <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> reappearance 1 year after inclusion, suggesting a reinfection and one seroconversion, probably acquired through blood transfusion was observed. This first longitudinal study including immunocompetent individuals confirms that <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> infection is common in Western Europe and that transfusion transmission occurs probably less frequently than expected. In addition, seroreversion and reinfection seem to be common. This suggests that the anti\u2010<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> may not persist overtime naturally. However, repeat exposure to the virus related to the high prevalence of <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> infection may result in a sustainable specific IgG response.<\/jats:p>","DOI":"10.1111\/jvh.12531","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:14:50Z","timestamp":1458371690000},"page":"569-575","source":"Crossref","is-referenced-by-count":24,"title":["New insights into the natural history of hepatitis E virus infection through a longitudinal study of multitransfused immunocompetent patients in France"],"prefix":"10.1111","volume":"23","author":[{"given":"A.","family":"Servant\u2010Delmas","sequence":"first","affiliation":[{"name":"Institut National de la Transfusion Sanguine (INTS) D\u00e9partement d'\u00e9tudes des Agents Transmissibles par le Sang Centre national de r\u00e9f\u00e9rence des h\u00e9patites virales B et C et du VIH en Transfusion Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Abravanel","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence H\u00e9patite E Institut F\u00e9d\u00e9ratif de Biologie CHU Toulouse Universit\u00e9 Toulouse III Toulouse France"},{"name":"INSERM U1043 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010J.","family":"Lefr\u00e8re","sequence":"additional","affiliation":[{"name":"Institut National de la Transfusion Sanguine (INTS) D\u00e9partement d'\u00e9tudes des Agents Transmissibles par le Sang Centre national de r\u00e9f\u00e9rence des h\u00e9patites virales B et C et du VIH en Transfusion Paris France"},{"name":"Universit\u00e9 Paris\u2010Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lionnet","sequence":"additional","affiliation":[{"name":"Hematology Unit Tenon Hospital AP\u2010HP  Paris 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