{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:59Z","timestamp":1791309899244,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK007191"],"award-info":[{"award-number":["T32 DK007191"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 DK078772"],"award-info":[{"award-number":["K24 DK078772"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 DK097142"],"award-info":[{"award-number":["K23 DK097142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009560","name":"American Gastroenterological Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23 DK099681"],"award-info":[{"award-number":["K23 DK099681"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Summary<\/jats:title>\n \n We examined the impact of\n HBV<\/jats:styled-content>\n \/\n HIV<\/jats:styled-content>\n coinfection on outcomes in hospitalized patients compared to those with\n HBV<\/jats:styled-content>\n or\n HIV<\/jats:styled-content>\n monoinfection. Using the 2011\n US<\/jats:styled-content>\n Nationwide Inpatient Sample, we identified patients who had been hospitalized with\n HBV<\/jats:styled-content>\n or\n HIV<\/jats:styled-content>\n monoinfection or\n HBV<\/jats:styled-content>\n \/\n HIV<\/jats:styled-content>\n coinfection using\n ICD<\/jats:styled-content>\n \u20109\u2010\n CM<\/jats:styled-content>\n codes. We compared liver\u2010related admissions between the three groups. Multivariable logistic regression was performed to identify independent predictors of in\u2010hospital mortality, length of stay and total charges. A total of 72 584 discharges with\n HBV<\/jats:styled-content>\n monoinfection, 133 880 discharges with\n HIV<\/jats:styled-content>\n monoinfection and 8156 discharges with\n HBV<\/jats:styled-content>\n \/\n HIV<\/jats:styled-content>\n coinfection were included.\n HBV<\/jats:styled-content>\n \/\n HIV<\/jats:styled-content>\n coinfection was associated with higher mortality compared to\n HBV<\/jats:styled-content>\n monoinfection (\n OR<\/jats:styled-content>\n 1.67, 95%\n CI<\/jats:styled-content>\n 1.30\u20132.15) but not when compared to\n HIV<\/jats:styled-content>\n monoinfection (\n OR<\/jats:styled-content>\n 1.22, 95%\n CI<\/jats:styled-content>\n 0.96\u20131.54). However, the presence of\n HBV<\/jats:styled-content>\n along with cirrhosis or complications of portal hypertension was associated with three times greater in\u2010hospital mortality in patients with\n HIV<\/jats:styled-content>\n compared to those without these complications (\n OR<\/jats:styled-content>\n 3.00, 95%\n CI<\/jats:styled-content>\n 1.80\u20135.02). Length of stay and total hospitalization charges were greater in the\n HBV<\/jats:styled-content>\n \u2010\/\n HIV<\/jats:styled-content>\n \u2010coinfected group compared to the\n HBV<\/jats:styled-content>\n monoinfection group (+1.53 days,\n P<\/jats:italic>\n < 0.001; $17595,\n P<\/jats:italic>\n < 0.001) and the\n HIV<\/jats:styled-content>\n monoinfection group (+0.62 days,\n P<\/jats:italic>\n = 0.034; $8840,\n P<\/jats:italic>\n = 0.005). In conclusion,\n HBV<\/jats:styled-content>\n \/\n HIV<\/jats:styled-content>\n coinfection is a risk factor for in\u2010hospital mortality, particularly in liver\u2010related admissions, compared to\n HBV<\/jats:styled-content>\n monoinfection. Overall healthcare utilization from\n HBV<\/jats:styled-content>\n \/\n HIV<\/jats:styled-content>\n coinfection is also higher than for either infection alone and higher than the national average for all hospitalizations, thus emphasizing the healthcare burden from these illnesses.\n <\/jats:p>","DOI":"10.1111\/jvh.12555","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T03:22:56Z","timestamp":1465788176000},"page":"820-829","source":"Crossref","is-referenced-by-count":43,"title":["HBV<\/scp>\n \/\n HIV<\/scp>\n coinfection is associated with poorer outcomes in hospitalized patients with\n HBV<\/scp>\n or\n HIV<\/scp>"],"prefix":"10.1111","volume":"23","author":[{"given":"R.","family":"Rajbhandari","sequence":"first","affiliation":[{"name":"Gastroenterology Division Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"},{"name":"Department of Medicine Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Jun","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Khalili","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"},{"name":"Department of Medicine Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"},{"name":"Department of Medicine Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. N.","family":"Ananthakrishnan","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"},{"name":"Department of Medicine Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_10_2_1","article-title":"Number of people (all ages) living with HIV data by WHO region","author":"WHO","year":"2012","journal-title":"World Heal Organ Glob Heal Obs"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(90)90209-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05062.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000163936.99401.fe"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832e463a"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000142"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/599110"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.15.1632"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.83534"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11913-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.5.1138"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290447"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37061"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/318501"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00126334-200007010-00003","article-title":"Mortality for liver disease in patients with HIV infection: a cohort study","volume":"24","author":"Puoti M","year":"2000","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000059"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01232.x"},{"key":"e_1_2_10_20_1","volume-title":"Agency for Healthcare Research and Quality","author":"HCUP Databases","year":"2014"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000171727.55553.78"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/653622"},{"issue":"3","key":"e_1_2_10_24_1","article-title":"Monitoring selected national HIV prevention and care objectives by using HIV surveillance data\u2013United States and 6 dependent areas\u20132012","volume":"19","author":"Centers for Disease Control and Prevention","year":"2014","journal-title":"HIV Surveillance Supplemental Report"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24804"},{"key":"e_1_2_10_26_1","article-title":"Viral Hepatitis. 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