{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:28:44Z","timestamp":1790252924525,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Summary<\/jats:title>\n \n It is still controversial, whether and to what amount cirrhosis and portal hypertension are reversible in patients with hepatitis C virus (\n HCV<\/jats:styled-content>\n )\u2010associated cirrhosis and sustained virologic response (\n SVR<\/jats:styled-content>\n ) after interferon\u2010free antiviral therapy. In this study, we prospectively evaluated dynamics of liver and spleen stiffness in\n HCV<\/jats:styled-content>\n \u2010infected patients with advanced liver disease and\n SVR<\/jats:styled-content>\n after interferon\u2010free treatment. A total of 54 patients with\n HCV<\/jats:styled-content>\n \u2010associated cirrhosis and\n SVR<\/jats:styled-content>\n were included. Liver and spleen stiffness was measured at therapy baseline (\n BL<\/jats:styled-content>\n ), end of treatment (\n EOT<\/jats:styled-content>\n ) and 24\u00a0weeks after\n EOT<\/jats:styled-content>\n (\n FU<\/jats:styled-content>\n 24) by transient liver elastography (L\u2010\n TE<\/jats:styled-content>\n ) as well as by acoustic radiation force impulse of the liver (L\u2010\n ARFI<\/jats:styled-content>\n ) and spleen (S\u2010\n ARFI<\/jats:styled-content>\n ), as well as biochemical, virologic and clinical data. Improvement of liver and spleen stiffness was found in 44 of 50 (88%), 31 of 54 (57%) and 25 of 54 (46%) of patients assessed by L\u2010\n TE<\/jats:styled-content>\n , L\u2010\n ARFI<\/jats:styled-content>\n and S\u2010\n ARFI<\/jats:styled-content>\n between baseline and\n FU<\/jats:styled-content>\n 24. Liver stiffness assessed by L\u2010\n TE<\/jats:styled-content>\n improved between\n BL<\/jats:styled-content>\n [median (range), 32.5 (9.1\u201375)\n kP<\/jats:styled-content>\n a] and\n EOT<\/jats:styled-content>\n [median (range), 21.3 (6.7\u201373.5)\n kP<\/jats:styled-content>\n a; (\n P<\/jats:italic>\n <.0001)], and between\n BL<\/jats:styled-content>\n and\n FU<\/jats:styled-content>\n 24 [median (range), 21.2 (5.4\u201370)\n kP<\/jats:styled-content>\n a; (\n P<\/jats:italic>\n <.0001)]. Liver stiffness assessed by L\u2010\n ARFI<\/jats:styled-content>\n improved between\n BL<\/jats:styled-content>\n [median (range), 2.7 (1.2\u20134.1) m\/s] and\n FU<\/jats:styled-content>\n 24 [median (range), 2.4 (1.2\u20133.9) m\/s;\n P<\/jats:italic>\n =.002), while spleen stiffness remained unchanged. Our data suggest that improvement of liver stiffness may be rather due to reduced necroinflammation and may be due to a less extent to regression of cirrhosis, as dynamics of liver stiffness improvement was more pronounced between\n BL<\/jats:styled-content>\n and\n EOT<\/jats:styled-content>\n than\n BL<\/jats:styled-content>\n and FU24.\n <\/jats:p>","DOI":"10.1111\/jvh.12578","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T14:27:59Z","timestamp":1470666479000},"page":"994-1002","source":"Crossref","is-referenced-by-count":142,"title":["Regression of fibrosis and portal hypertension in\n HCV<\/scp>\n \u2010associated cirrhosis and sustained virologic response after interferon\u2010free antiviral therapy"],"prefix":"10.1111","volume":"23","author":[{"given":"V.","family":"Knop","sequence":"first","affiliation":[{"name":"Medizinische Klinik 1 Universit\u00e4tsklinikum Frankfurt Frankfurt am Main 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