{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:37:56Z","timestamp":1759178276281},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Summary<\/jats:title>Sofosbuvir\/ledipasvir (SOF<\/jats:styled-content>\/LDV<\/jats:styled-content>) is the first all\u2010oral ribavirin\u2010free treatment approved for chronic hepatitis C virus (HCV<\/jats:styled-content>) genotype 6, offering a safe and highly efficacious treatment option. Large studies evaluating real\u2010world outcomes of this regimen are lacking. We aim to evaluate real\u2010world treatment outcomes for HCV<\/jats:styled-content> genotype 6. A retrospective cohort study evaluated 65 adults (age \u226518) with chronic HCV<\/jats:styled-content> genotype 6 treated with SOF<\/jats:styled-content>\/LDV<\/jats:styled-content> without ribavirin at a community gastroenterology clinic in the United States from November 2014 to May 2016. Rates of undetectable virus at week 4 on treatment, at end of treatment (EOT<\/jats:styled-content>) and SVR<\/jats:styled-content>12 were stratified by the presence of cirrhosis and prior treatment (treatment na\u00efve vs treatment experienced). Among 65 patients with chronic HCV<\/jats:styled-content> genotype 6 treated with SOF<\/jats:styled-content>\/LDV<\/jats:styled-content> (52.3% male, mean age 66.3\u00a0years [SD<\/jats:styled-content> 9.7], 41.5% cirrhosis and 15.4% treatment experienced), 97.3% had undetectable virus at week 4 on treatment, 96.9% had undetectable virus at EOT<\/jats:styled-content> and 95.3% achieved SVR<\/jats:styled-content>12. SVR<\/jats:styled-content>12 was 100% in females vs 91.2% in males, P<\/jats:italic>=.096, and 92.3% in patients with cirrhosis vs 97.4% in those without cirrhosis, P<\/jats:italic>=.347. Resistance testing of treatment failures was attempted but unsuccessful due to lack of conforming primers to define the possible resistance mutations. Among the largest U.S. community\u2010based real\u2010world cohort of Asian chronic HCV<\/jats:styled-content> genotype 6 patients treated with all\u2010oral SOF<\/jats:styled-content>\/LDV<\/jats:styled-content> without ribavirin, SVR<\/jats:styled-content>12 was similar to SVR<\/jats:styled-content>12 reported in clinical trials, confirming the safety and effectiveness of this regimen and validating current HCV<\/jats:styled-content> genotype 6 treatment guideline recommendations.<\/jats:p>","DOI":"10.1111\/jvh.12609","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T03:43:51Z","timestamp":1475034231000},"page":"17-21","source":"Crossref","is-referenced-by-count":15,"title":["Community\u2010based real\u2010world treatment outcomes of sofosbuvir\/ledipasvir in Asians with chronic hepatitis C virus genotype 6 in the United States"],"prefix":"10.1111","volume":"24","author":[{"given":"R. J.","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Alameda Health System \u2013 Highland Hospital Oakland CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Silicon Valley Research Institute San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. N.","family":"Trinh","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Huynh","sequence":"additional","affiliation":[{"name":"Silicon Valley Research Institute San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Ly","sequence":"additional","affiliation":[{"name":"Silicon Valley Research Institute San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yang","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Garcia","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Levitt","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"da Silveira","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology San Jose CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Gish","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford Health Care Stanford CA USA"},{"name":"National Viral Hepatitis Roundtable San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27259"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.027"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26218"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.11.039"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26986"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7085"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.6011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27736"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23889"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214853"},{"key":"e_1_2_7_13_1","unstructured":"AASLD\u2010IDSA.Recommendations for testing m and treating hepatitis C.2016.www.hcvguidelines.org. 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