{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:00:44Z","timestamp":1790402444263,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T00:00:00Z","timestamp":1475193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500665"],"award-info":[{"award-number":["81500665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16H160047"],"award-info":[{"award-number":["LY16H160047"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Summary<\/jats:title>At present, there is no ideal model for predicting the short\u2010term outcome of patients with acute\u2010on\u2010chronic hepatitis B liver failure (ACHBLF<\/jats:styled-content>). This study aimed to establish and validate a prognostic model by using the classification and regression tree (CART<\/jats:styled-content>) analysis. A total of 1047 patients from two separate medical centres with suspected ACHBLF<\/jats:styled-content> were screened in the study, which were recognized as derivation cohort and validation cohort, respectively. CART<\/jats:styled-content> analysis was applied to predict the 3\u2010month mortality of patients with ACHBLF<\/jats:styled-content>. The accuracy of the CART<\/jats:styled-content> model was tested using the area under the receiver operating characteristic curve, which was compared with the model for end\u2010stage liver disease (MELD<\/jats:styled-content>) score and a new logistic regression model. CART<\/jats:styled-content> analysis identified four variables as prognostic factors of ACHBLF<\/jats:styled-content>: total bilirubin, age, serum sodium and INR<\/jats:styled-content>, and three distinct risk groups: low risk (4.2%), intermediate risk (30.2%\u201053.2%) and high risk (81.4%\u201096.9%). The new logistic regression model was constructed with four independent factors, including age, total bilirubin, serum sodium and prothrombin activity by multivariate logistic regression analysis. The performances of the CART<\/jats:styled-content> model (0.896), similar to the logistic regression model (0.914, P<\/jats:italic>=.382), exceeded that of MELD<\/jats:styled-content> score (0.667, P<\/jats:italic><.001). The results were confirmed in the validation cohort. We have developed and validated a novel CART<\/jats:styled-content> model superior to MELD<\/jats:styled-content> for predicting three\u2010month mortality of patients with ACHBLF<\/jats:styled-content>. Thus, the CART<\/jats:styled-content> model could facilitate medical decision\u2010making and provide clinicians with a validated practical bedside tool for ACHBLF<\/jats:styled-content> risk stratification.<\/jats:p>","DOI":"10.1111\/jvh.12617","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T07:03:15Z","timestamp":1475218995000},"page":"132-140","source":"Crossref","is-referenced-by-count":23,"title":["Classification and regression tree analysis of acute\u2010on\u2010chronic hepatitis B liver failure: Seeing the forest for the trees"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-3834","authenticated-orcid":false,"given":"K.\u2010Q.","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Hepatology Liver Research Center The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Institute of Hepatology Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010Y.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jinhua Municipal Hospital Jinhua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010D.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Ningbo No. 2 Hospital Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Tianjin Infectious Disease Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatology Liver Research Center The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Institute of Hepatology Wenzhou Medical University Wenzhou 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