{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:15:28Z","timestamp":1790662528827,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T00:00:00Z","timestamp":1478217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007766","name":"Max-Planck-Institut f\u00fcr Kognitions- und Neurowissenschaften","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007766","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic hepatitis C virus (HCV) infection is associated with fatigue and depression. Cognitive impairments are also reported in a smaller number of HCV\u2010positive patients. Recent studies linked HCV to low\u2010grade inflammation in brain. Here, we test the hypothesis that chronic HCV is associated with 3T\u2010neuroimaging\u2010derived grey matter volume (GMV) and functional connectivity alterations in a sample of chronic HCV (1b), without severe liver disease. Regional GMV and resting\u2010state fMRI\u2010derived eigenvector centrality (EC) were compared between 19 HCV\u2010positive patients and 23 healthy controls (all females, 50\u201069 and 52\u201064\u00a0years, respectively), controlling for white matter hyperintensities and age. Standard tests were used to assess fatigue, depression and cognitive performance. Also, liver fibrosis stage and viral load were quantified among patients. In comparison with controls, HCV\u2010positive patients had higher scores in fatigue and depression, and worse alertness scores. The groups performed similarly in other cognitive domains. We report higher EC in a cluster in the right anterior superior parietal lobule in patients, while no differences are found in GMV. Post hoc functional connectivity analysis showed increased connectivity of this cluster with primary and secondary somatosensory cortex, and temporal and occipital lobes in patients. Higher mean EC in the superior parietal cluster, adjusted for mean framewise displacement, was associated with better memory and attention performance, but not with fatigue, depression, viral load or level of liver fibrosis, among patients. These results suggest a compensatory mechanism in chronic hepatitis C and explain equivocal results in the literature about cognitive deficits in infected persons. Further studies should define the relation of these connectivity changes to the brain's inflammatory activity.<\/jats:p>","DOI":"10.1111\/jvh.12634","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T05:33:24Z","timestamp":1478237604000},"page":"216-225","source":"Crossref","is-referenced-by-count":15,"title":["Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study"],"prefix":"10.1111","volume":"24","author":[{"given":"S.","family":"Kharabian Masouleh","sequence":"first","affiliation":[{"name":"Department of Neurology Max Planck Institute for Cognitive and Brain Sciences  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Herzig","sequence":"additional","affiliation":[{"name":"Clinic for Cognitive Neurology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Klose","sequence":"additional","affiliation":[{"name":"Clinic for Cognitive Neurology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Roggenhofer","sequence":"additional","affiliation":[{"name":"Department of Neurology Max Planck Institute for Cognitive and Brain Sciences  Leipzig Germany"},{"name":"LREN Department for Clinical Neurosciences CHUV University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tenckhoff","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Gastroenterology and Rheumatology University Hospital  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Th\u00f6ne\u2010Otto","sequence":"additional","affiliation":[{"name":"Clinic for Cognitive Neurology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wiese","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Gastroenterology and Rheumatology University Hospital  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Berg","sequence":"additional","affiliation":[{"name":"Section of Hepatology Department of Gastroenterology and Rheumatology University Hospital  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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