{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:59:41Z","timestamp":1761663581256},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402733","81273145"],"award-info":[{"award-number":["81402733","81273145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Understanding the biology of spontaneous clearance of hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection could lead to improved strategies to prevent the sequelae associated with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection. Chronic infections with hepatitis virus are very common in China, but the factors associated with spontaneous clearance of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> have not been adequately studied. We evaluated the spontaneous clearance of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> among 1918 drug users and 1526 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010seropositive blood donors in Guangzhou, China. Among participants who were co\u2010infected with hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>), 41.38% of drug users and 39.47% of blood donors had cleared their <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection without antiviral therapy compared to 9.41% of drug users and 16.73% of blood donors who were mono\u2010infected with a single virus (<jats:italic>P<\/jats:italic>&lt;.01). The proportion of subjects who had cleared their <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection was significantly greater in the co\u2010infected subjects whose serum <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> was greater than 2000<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/mL than those with lower levels. A multiple logistic regression analysis found female gender, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B rs8099917 <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype, <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> co\u2010infection and blood donors (vs drug users) associated with increased spontaneous clearance of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection. Although acute <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infections are common in China, the incidence of chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> may be reduced among the high prevalence of chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B genotypes associated with spontaneous clearance of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> in Chinese populations.<\/jats:p>","DOI":"10.1111\/jvh.12644","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T05:33:00Z","timestamp":1481520780000},"page":"312-319","source":"Crossref","is-referenced-by-count":12,"title":["<scp>HBV<\/scp>\/<scp>HCV<\/scp> co\u2010infection is associated with a high level of <scp>HCV<\/scp> spontaneous clearance among drug users and blood donors in China"],"prefix":"10.1111","volume":"24","author":[{"given":"H.","family":"Xiong","sequence":"first","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Rong","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine School of Biotechnology Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine School of Biotechnology Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Shan","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Infectious Diseases Department of Epidemiology and Biostatistics University of Georgia  Athens GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Bloomberg School of Public Health Johns Hopkins University  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Fu","sequence":"additional","affiliation":[{"name":"Guangzhou Blood Center  Guangzhou Guangdong China"},{"name":"The Key Medical Disciplines and Specialties Program of Guangzhou  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70216-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.027"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i10.1377"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.107"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2011.0052"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2005.00651.x"},{"key":"e_1_2_7_8_1","first-page":"52","article-title":"Ianchenko VI [Spontaneous HCV clearance: an association with gender, age, viral genotypes, infection transmission routes, and markers of HBV and HIV]","volume":"82","author":"Fedorchenko SV","year":"2010","journal-title":"Ter Arkh"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70010-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22271"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200510000-00013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1155\/2008\/970702","article-title":"Ethnicity and spontaneous clearance of hepatitis C in HIV\u2010HCV coinfected patients","volume":"19","author":"Miedzinski L","year":"2008","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1985-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.04.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ562"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12198"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.4.450"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.560207.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv220"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22794"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08435-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40670.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27337"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22794"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.09.023"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840400419"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.7.2084-2086.1998"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22951"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80044-8"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009512"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/383279"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00003"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir835"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61116-2"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12644","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:34:30Z","timestamp":1696178070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,12]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jvh.12644"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12644","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,12]]}}}