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style=\"fixed-case\">HBV<\/jats:styled-content>) reactivation during or after chemotherapy in patients with breast cancer has become a remarkable clinical problem. Prophylactic nucleos(t)ide analogues (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>s) are recommended for patients with breast cancer who are hepatitis B surface antigen (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg) positive before chemotherapy. We performed an up\u2010to\u2010date meta\u2010analysis to compare the efficacy of prophylactic lamivudine use with nonprophylaxis in <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010positive breast cancer patients undergoing chemotherapy. PubMed, the Cochrane Library and China National Knowledge Infrastructure (<jats:styled-content style=\"fixed-case\">CNKI<\/jats:styled-content>) databases were searched for relevant articles until June 2016. Eligible articles comparing the efficacy of prophylactic lamivudine use with nonprophylaxis in <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010positive breast cancer patients undergoing chemotherapy were identified. Eight studies which had enrolled 709 <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010positive breast cancer patients undergoing chemotherapy were analysed. Lamivudine prophylaxis significantly reduced the rates of chemotherapy\u2010associated hepatitis B flares in chronic hepatitis B in breast cancer compared with patients with nonprophylaxis (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]=0.15, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 0.07\u20100.35, <jats:italic>P<\/jats:italic>&lt;.00001). Chemotherapy disruption rates attributed to <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation in the prophylaxis groups were significantly lower than the nonprophylaxis groups (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=0.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.07\u20100.43, <jats:italic>P<\/jats:italic>=.0002). Patients with lamivudine prophylaxis had a higher risk for tyrosine\u2010methionine\u2010aspartate\u2010aspartate (<jats:styled-content style=\"fixed-case\">YMDD<\/jats:styled-content>) motif mutations than patients with nonprophylaxis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=6.33, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.01\u201039.60, <jats:italic>P<\/jats:italic>=.05). Prophylactic antiviral therapy management is necessary for <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010positive breast cancer patients undergoing chemotherapy, in spite of high correlation with lamivudine\u2010resistant <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> variants with <jats:styled-content style=\"fixed-case\">YMDD<\/jats:styled-content> motif mutations.<\/jats:p>","DOI":"10.1111\/jvh.12672","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T15:27:45Z","timestamp":1484062065000},"page":"561-572","source":"Crossref","is-referenced-by-count":22,"title":["Hepatitis B virus reactivation in breast cancer patients undergoing chemotherapy: A review and meta\u2010analysis of prophylaxis management"],"prefix":"10.1111","volume":"24","author":[{"given":"Z.","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetic and Gene 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