{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:27:48Z","timestamp":1780990068280,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report the largest study on the prevalence and distribution of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotypes in Spain (2000\u20102015), and we relate them with clinical, epidemiological and virological factors. Patients from 29 hospitals in 10 autonomous communities (Andalusia, Aragon, Castilla\u2010Leon, Catalonia, Galicia, Canary Islands, Madrid Community, Valencian Community, Murcia Region and Basque Country) have been studied. Annual distribution of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotypes and subtypes, as well as gender, age, transmission route, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> coinfection, and treatment details were recorded. We included 48595 chronically <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected patients with the following characteristics: median age 51 years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 44\u201058), 67.9% male, 19.1% <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010coinfected, 23.5% <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010coinfected. Parenteral transmission route was the most frequent (58.7%). Genotype distribution was 66.9% <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>1 (24.9% subtype 1a and 37.9% subtype 1b), 2.8% <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>2, 17.3% <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>3, 11.4% <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>4 and 0.1% <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>5 and 0.02% <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>6. Li<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> was the most widely <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotyping test used (52.4%). <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> subtype 1a and genotypes 3 and 4 were closely associated with male gender, parenteral route of infection and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> coinfection; in contrast, subtype 1b and genotype 2 were associated with female gender, nonparenteral route and mono\u2010infection. Age was related to genotype distribution, and different patterns of distribution and biodiversity index were observed between different geographical areas. Finally, we describe how treatment and changes in transmission routes may have affected <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype prevalence and distribution patterns. We present the most recent data on molecular epidemiology of hepatitis C virus in Spain. This study confirms that genotype distributions vary with age, sex, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> coinfection and within geographical areas and epidemiological groups.<\/jats:p>","DOI":"10.1111\/jvh.12700","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T14:57:12Z","timestamp":1488380232000},"page":"725-732","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000\u20102015 period (the <scp>GEHEP<\/scp> 005 study)"],"prefix":"10.1111","volume":"24","author":[{"given":"A.","family":"Aguilera","sequence":"first","affiliation":[{"name":"Complexo Hospitalario Universitario de Santiago de Compostela  A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Santiago de Compostela  A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rodr\u00edguez\u2010Frias","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Viciana","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Victoria  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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