{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:10:59Z","timestamp":1780528259146,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UCLA AIDS Institute\/Center for AIDS Research","award":["P30AI028697"],"award-info":[{"award-number":["P30AI028697"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Summary<\/jats:title>Chronic hepatitis C virus (HCV<\/jats:styled-content>) infection has been associated with an increased risk for cardiovascular disease (CVD<\/jats:styled-content>). The recommended Pooled Cohort atherosclerotic cardiovascular disease (ASCVD<\/jats:styled-content>) risk equation for estimation of 10\u2010year CVD<\/jats:styled-content> risk has not been validated in HCV<\/jats:styled-content>\u2010infected populations. We examined the performance of the ASCVD<\/jats:styled-content> risk score in HCV<\/jats:styled-content>\u2010infected persons, using the national Electronically Retrieved Cohort of HCV<\/jats:styled-content> Infected Veterans to derive a cohort of HCV<\/jats:styled-content>\u2010infected and uninfected subjects without baseline ASCVD<\/jats:styled-content>, hepatitis B, or HIV<\/jats:styled-content> infection, and with low\u2010density lipoprotein cholesterol level<190\u00a0mg\/dL<\/jats:styled-content>. Performance of the ASCVD<\/jats:styled-content> risk equation was assessed by Cox proportional hazard regression, C\u2010statistics and Hosmer\u2010Lemeshow statistic. The cohort included 70\u00a0490 HCV<\/jats:styled-content>\u2010infected and 97\u00a0766 HCV<\/jats:styled-content>\u2010uninfected men with mean age of 55\u00a0years, 56% White and 29% Black. Incident CVD<\/jats:styled-content> event rates were similar between the two groups (13.2 and 13.4 events\/1000 person\u2010years), with a higher incidence of coronary heart disease events in the HCV<\/jats:styled-content>\u2010uninfected group and of stroke events in the HCV<\/jats:styled-content>\u2010infected group. Adjusting for ASCVD<\/jats:styled-content> risk score, HCV<\/jats:styled-content> infection was associated with higher risk for an ASCVD<\/jats:styled-content> event in the subgroup with baseline ASCVD<\/jats:styled-content> risk \u22657.5% (HR<\/jats:styled-content>: 1.19, P<\/jats:italic><.0001). C\u2010statistics were poor in both the HCV<\/jats:styled-content>\u2010infected and uninfected groups (0.60 and 0.61, respectively). By Hosmer\u2010Lemeshow test, the ASCVD<\/jats:styled-content> risk equation overestimated risk amongst lower risk patients and underestimated risk amongst higher risk patients in both the HCV<\/jats:styled-content>\u2010infected and uninfected groups. Further investigation is needed to determine whether a modified equation to accurately predict ASCVD<\/jats:styled-content> risk in HCV<\/jats:styled-content>\u2010infected persons is warranted.<\/jats:p>","DOI":"10.1111\/jvh.12705","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T18:32:48Z","timestamp":1488997968000},"page":"814-822","source":"Crossref","is-referenced-by-count":14,"title":["Performance of the Pooled Cohort atherosclerotic cardiovascular disease risk score in hepatitis C virus\u2010infected persons"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-4348","authenticated-orcid":false,"given":"K. W.","family":"Chew","sequence":"first","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. B.","family":"Horwich","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Yan","sequence":"additional","affiliation":[{"name":"VA Pittsburgh Healthcare System Pittsburgh PA USA"},{"name":"Department of Medicine University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"McGinnis","sequence":"additional","affiliation":[{"name":"VA Pittsburgh Healthcare System Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Freiberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University School of Medicine Nashville TN USA"},{"name":"VA Tennessee Valley Healthcare System Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Currier","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Butt","sequence":"additional","affiliation":[{"name":"VA Pittsburgh Healthcare System Pittsburgh PA USA"},{"name":"Weill Cornell Medical College Doha Qatar"},{"name":"Weill Cornell Medical College New York NY USA"},{"name":"Hamad Medical Corporation Doha Qatar"},{"name":"Hamad Healthcare Quality Institute Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07339-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/599371"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0459"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.01.051"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.09.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.09.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.12.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437741.48606.98"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.08.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.337"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031527"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00885.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03020.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099150"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000223670.00890.74"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31817d69c2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.4.522"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-009-0028-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106376"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.10.005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.032"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:09:19Z","timestamp":1696165759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jvh.12705"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12705","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]}}}