{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:48:17Z","timestamp":1791668897375,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Summary<\/jats:title>Portal hypertension is a predictor of liver\u2010related clinical events and mortality in patients with hepatitis C and cirrhosis. The effect of interferon\u2010free hepatitis C treatment on portal pressure is unknown. Fifty patients with Child\u2010Pugh\u2010Turcotte (CPT<\/jats:styled-content>) A and B cirrhosis and portal hypertension (hepatic venous pressure gradient [HVPG<\/jats:styled-content>] >6\u00a0mm Hg) were randomized to receive 48\u00a0weeks of open\u2010label sofosbuvir plus ribavirin at Day 1 or after a 24\u2010week observation period. The primary endpoint was sustained virologic response 12\u00a0weeks after therapy (SVR<\/jats:styled-content>12) in patients who received \u22651 dose of treatment. Secondary endpoints included changes in HVPG<\/jats:styled-content>, laboratory parameters, and MELD<\/jats:styled-content> and CPT<\/jats:styled-content> scores. A subset of patients was followed 48\u00a0weeks posttreatment to determine late changes in HVPG<\/jats:styled-content>. SVR<\/jats:styled-content>12 occurred in 72% of patients (33\/46). In the 37 patients with paired HVPG<\/jats:styled-content> measurements at baseline and the end of treatment, mean HVPG<\/jats:styled-content> decreased by \u20101.0 (SD<\/jats:styled-content> 3.97) mm Hg. Nine patients (24%) had \u226520% decreases in HVPG<\/jats:styled-content> during treatment. Among 39 patients with pretreatment HVPG<\/jats:styled-content> \u226512\u00a0mm Hg, 27 (69%) achieved SVR<\/jats:styled-content>12. Four of the 33 (12%) patients with baseline HVPG<\/jats:styled-content> \u226512\u00a0mm Hg had HVPG<\/jats:styled-content> <12\u00a0mm Hg at the end of treatment. Of nine patients with pretreatment HVPG<\/jats:styled-content> \u226512\u00a0mm Hg who achieved SVR<\/jats:styled-content>12 and completed 48\u00a0weeks of follow\u2010up, eight (89%) had a \u226520% reduction in HVPG<\/jats:styled-content>, and three reduced their pressure to <12\u00a0mm Hg. Patients with chronic HCV<\/jats:styled-content> and compensated or decompensated cirrhosis who achieve SVR<\/jats:styled-content> can have clinically meaningful reductions in HVPG<\/jats:styled-content> at long\u2010term follow\u2010up. (EudraCT<\/jats:styled-content> 2012\u2010002457\u201029).<\/jats:p>","DOI":"10.1111\/jvh.12706","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:42:11Z","timestamp":1489167731000},"page":"823-831","source":"Crossref","is-referenced-by-count":110,"title":["Effect of viral suppression on hepatic venous pressure gradient in hepatitis C with cirrhosis and portal hypertension"],"prefix":"10.1111","volume":"24","author":[{"given":"N.","family":"Afdhal","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. T.","family":"Everson","sequence":"additional","affiliation":[{"name":"University of Colorado Denver Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Calleja","sequence":"additional","affiliation":[{"name":"Hospital U. Puerta de Hierro CIBEREHD Universidad Autonoma Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. W.","family":"McCaughan","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital, Centenary Research Institute University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Clinic, IDIBAPS CIBEREHD Barcelona Spain"},{"name":"Swiss Liver Center, Inselspital Bern University Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Brainard","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc. Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"McHutchison","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc. Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"De\u2010Oertel","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc. Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"An","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Inc. Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Charlton","sequence":"additional","affiliation":[{"name":"Intermountain Medical Center Murray Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4898-7778","authenticated-orcid":false,"given":"K. R.","family":"Reddy","sequence":"additional","affiliation":[{"name":"University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Asselah","sequence":"additional","affiliation":[{"name":"H\u00f4pital Beaujon, Department of Hepatology, AP\u2010HP INSERM UMR1149 and University Paris\u2010Diderot Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gane","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Curry","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Forns","sequence":"additional","affiliation":[{"name":"Liver Unit, Hospital Clinic, IDIBAPS CIBEREHD Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23478"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/706032"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2014.20.1.6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50133"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00743.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.02.022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20062"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-951603"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20871"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512614"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00052-9"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:09:21Z","timestamp":1696165761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jvh.12706"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12706","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]}}}