{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:10:08Z","timestamp":1779923408426,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acute hepatitis C virus infection remains a major health concern in human immunodeficiency virus(HIV)\u2010infected men who have sex with men (<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>). New direct\u2010acting antiviral agent (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>) combination therapy has not yet been approved for the treatment for acute hepatitis C virus(HCV), thereby potentially causing deferral of<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>treatment. Therefore, we aimed to study the course of liver disease after an episode of acute<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. This study is a retrospective single\u2010centre cohort of<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>with acute<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>infection. Liver fibrosis was estimated by Fibroscan<jats:sup>\u00ae<\/jats:sup>and Fibrotest<jats:sup>\u00ae<\/jats:sup>. Liver\u2010related and non\u2010liver\u2010related outcomes were documented. Overall 213 episodes of acute<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>infection in 178 men were documented. Median follow\u2010up for all included patients was 38.7\u00a0months. Spontaneous<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>clearance was found in 10.8% of patients, which was significantly associated with older age, lower<jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>levels, and higher<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>levels upon initial acute<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>diagnosis. Treatment with interferon\u2010based therapy was initiated in 86.3% of cases, resulting in a sustained virological response(SVR) rate of 70.7%. After 3\u00a0years\u2019 follow\u2010up, significant liver fibrosis of<jats:styled-content style=\"fixed-case\">METAVIR<\/jats:styled-content>F2 stage or higher was found in 39.4% of patients after first acute<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>diagnosis. Higher age, physician\u2010declared alcoholism, and nonresponse to acute<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>therapy were independently associated with higher fibrosis stages. Ten patients died during the observation period (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>1.4\/100 patient\u2010years) and four during interferon treatment. Significant liver fibrosis is a common finding in<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>following acute<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>infection despite high treatment uptake and cure rates, suggesting the need for close liver disease monitoring particularly if<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>treatment is deferred.<\/jats:p>","DOI":"10.1111\/jvh.12707","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T07:33:34Z","timestamp":1493105614000},"page":"832-839","source":"Crossref","is-referenced-by-count":13,"title":["<scp>HIV<\/scp>\u2010positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis 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