{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T21:37:43Z","timestamp":1770673063033,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2012ZX10002001"],"award-info":[{"award-number":["2012ZX10002001"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We describe the epidemiology of hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) infection among women of reproductive age residing in areas of China that are highly endemic for chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>, and provide evidence useful for decision\u2010makers to guide strategies for preventing mother\u2010to\u2010child transmission of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>, and assess the impact of perinatal transmission <jats:styled-content style=\"fixed-case\">PMTCT<\/jats:styled-content> by projecting <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg prevalence trends without interventions. We conducted a cross\u2010sectional <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> serological survey of women, 15\u201049\u00a0years of age, residing in Fujian, Guangdong, Guangxi and Hainan provinces. Demographic and other subject\u2010level data were collected in face\u2010to\u2010face interviews, after which we obtain blood specimens. Specimens were tested for <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> sero\u2010markers by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> (Beijing Wantai Biological Pharmacy), and <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> was tested with <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> (Hunan Sansure Biotech). Weighted <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> (either <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg+ or anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c+ indicating either present or past infection) prevalences were 11.82% and 57.16%, respectively. Among the <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010positive women, 27% were also <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg positive. The proportion of individuals with <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> loads &gt;10<jats:sup>5<\/jats:sup>IU\/mL declined with increasing age. Among <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010negative women, 0.9% had occult <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection. The prevalence of chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection among reproductive women in these highly endemic provinces is high, posing a threat to maternal health and risk of mother\u2010to\u2010child transmission. Prevention of mother\u2010to\u2010child transmission remains critically important.<\/jats:p>","DOI":"10.1111\/jvh.12757","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T07:42:40Z","timestamp":1503474160000},"page":"88-96","source":"Crossref","is-referenced-by-count":17,"title":["The epidemiology of hepatitis B virus infection in women of reproductive age in highly endemic areas in China"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8310-1568","authenticated-orcid":false,"given":"H.","family":"Zheng","sequence":"first","affiliation":[{"name":"Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Q.","family":"Cui","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Z.","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. F.","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Center for Disease Control and Prevention  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. P.","family":"Shao","sequence":"additional","affiliation":[{"name":"Guangdong Center for Disease Control and Prevention  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Du","sequence":"additional","affiliation":[{"name":"Guangxi Center for Disease Control and Prevention  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"Hainan Center for Disease Control and Prevention  Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fujian Center for Disease Control and Prevention  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Z.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangdong Center for Disease Control and Prevention  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T.","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Guangxi Center for Disease Control and Prevention  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. X.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hainan Center for Disease Control and Prevention  Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Miao","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. J.","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. 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