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classes relate to phylogenetic clustering of hepatitis C virus (HCV) infection. HCV antibody\u2010positive people who use drugs from two cohorts in Vancouver, Canada (1996\u20102012), with a Core\u2010E2 sequence were included. Time\u2010stamped phylogenetic trees were inferred, and phylogenetic clustering was determined by time to most common recent ancestor. Latent classes were estimated, and the association with the phylogenetic clustering outcome was assessed using an inclusive classify\/analyse approach. Among 699 HCV RNA\u2010positive participants (26% female, 24% HIV+), recent drug use included injecting cocaine (80%), injecting heroin (70%), injecting cocaine\/heroin (ie, speedball, 38%) and crack cocaine smoking (28%). Latent class analysis identified four distinct subgroups of drug use typologies: (i) cocaine injecting, (ii) opioid and cocaine injecting, (iii) crack cocaine smoking and (iv) heroin injecting and currently receiving opioid substitution therapy. After adjusting for age and HIV infection, compared to the group defined by heroin injecting and currently receiving opioid substitution therapy, the odds of phylogenetic cluster membership was greater in the cocaine injecting group (adjusted OR [aOR]: 3.06; 95% CI: 1.73, 5.42) and lower in the crack cocaine smoking group (aOR: 0.06; 95% CI: 0.01, 0.48). Combining latent class and phylogenetic clustering analyses provides novel insights into the complex dynamics of HCV transmission. Incorporating differing risk profiles associated with drug use may provide opportunities to further optimize and target HCV treatment and prevention strategies.<\/jats:p>","DOI":"10.1111\/jvh.12758","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T12:35:50Z","timestamp":1500381350000},"page":"28-36","source":"Crossref","is-referenced-by-count":5,"title":["Drug use and phylogenetic clustering of hepatitis C virus infection among people who use drugs in Vancouver, Canada: A latent class analysis approach"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5910-853X","authenticated-orcid":false,"given":"B.","family":"Jacka","sequence":"first","affiliation":[{"name":"Viral Hepatitis Clinical Research Program The Kirby Institute UNSW Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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