{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:05:07Z","timestamp":1788743107607,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T00:00:00Z","timestamp":1509235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570535"],"award-info":[{"award-number":["81570535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["134119a2400"],"award-info":[{"award-number":["134119a2400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["12XD1403600"],"award-info":[{"award-number":["12XD1403600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Summary<\/jats:title>Transient elastography (TE<\/jats:styled-content>) is accurate in staging fibrosis noninvasively. However, a reliable serum biomarker with comparable accuracy is also important, especially when TE<\/jats:styled-content> is unreliable\/unavailable. Therefore, we aimed to evaluate the diagnostic performance of serum Golgi protein 73 (GP<\/jats:styled-content>73) for significant fibrosis in patients with chronic HBV<\/jats:styled-content> infection. A total of 801 patients with chronic liver disease (CLD; 492 chronic HBV<\/jats:styled-content> infection and 309 non\u2010HBV<\/jats:styled-content> liver disease) with liver biopsy performance were enrolled. Healthy controls (n\u00a0=\u00a0180) and hepatocellular carcinoma (HCC<\/jats:styled-content>) patients (n\u00a0=\u00a085) were included for comparisons. Liver biopsy was used as the reference method for fibrosis staging. Serum GP<\/jats:styled-content>73 level was measured in duplicate in double\u2010blind fashion. Serum GP<\/jats:styled-content>73 was highest in HCC<\/jats:styled-content> but also significantly higher in chronic hepatitis B than in healthy controls. The elevation of serum GP<\/jats:styled-content>73 in non\u2010HCC<\/jats:styled-content> patients was significantly associated with the presence of significant fibrosis independently of ALT<\/jats:styled-content> level, liver stiffness (LS) value, inflammation grade and other confounding factors. The diagnostic performance of serum GP<\/jats:styled-content>73 was accurate in antiviral\u2010na\u00efve HBV<\/jats:styled-content> patients (area under the receiver operating curve [AUROC<\/jats:styled-content>], 0.76 95% CI<\/jats:styled-content>: 0.72\u20100.81) but not in patients with ongoing antiviral treatment (AUROC<\/jats:styled-content>, 0.60). The utility of serum GP<\/jats:styled-content>73 was also confirmed in non\u2010HBV<\/jats:styled-content> CLD (AUROC<\/jats:styled-content>, 0.80 95% CI<\/jats:styled-content>: 0.75\u20100.85). Serum GP<\/jats:styled-content>73 was comparable to LS (AUROC<\/jats:styled-content>, 0.78 95% CI<\/jats:styled-content>: 0.73\u20100.82) and significantly better than AST to platelet ratio index (APRI<\/jats:styled-content>) (AUROC<\/jats:styled-content>, 0.67 95% CI<\/jats:styled-content>: 0.62\u20100.72) and FIB<\/jats:styled-content>\u20104 (AUROC<\/jats:styled-content>, 0.68 95% CI<\/jats:styled-content>: 0.63\u20100.73). In conclusion, serum GP<\/jats:styled-content>73 is an accurate serum marker for significant fibrosis in chronic HBV<\/jats:styled-content> infection, with higher accuracy than APRI<\/jats:styled-content> and FIB<\/jats:styled-content>\u20104. Serum GP<\/jats:styled-content>73 is potentially a complementary tool for TE<\/jats:styled-content> when evaluating the necessity of antiviral treatment, particularly in patients without definite antiviral indication.<\/jats:p>","DOI":"10.1111\/jvh.12786","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T02:50:13Z","timestamp":1509331813000},"page":"57-65","source":"Crossref","is-referenced-by-count":34,"title":["Assessment of serum Golgi protein 73 as a biomarker for the diagnosis of significant fibrosis in patients with chronic HBV<\/scp> infection"],"prefix":"10.1111","volume":"24","author":[{"given":"Z.","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Ruijin 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