{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:39:49Z","timestamp":1790098789299,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["3347C0\u2010108782\/1"],"award-info":[{"award-number":["3347C0\u2010108782\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["33CS30\u2010148417\/1"],"award-info":[{"award-number":["33CS30\u2010148417\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In order to accurately assess the burden of hepatitis C (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) and develop effective interventions, we must understand the magnitude and trends of mortality related to the disease. In the United States, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality is continuously increasing. We have no comparable data for Switzerland and other European countries, although a modelling study predicted a similar increase. We analysed time trends (1 January 1995\u201031 December 2014) in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010specific mortality rates in the Swiss general population using the death registry of the Swiss Federal Statistical Office (<jats:styled-content style=\"fixed-case\">SFSO<\/jats:styled-content>). We compared <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality to <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related and hepatitis B (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>)\u2010related mortality. To determine potential under\u2010reporting in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality, we probabilistically linked the <jats:styled-content style=\"fixed-case\">SFSO<\/jats:styled-content> data to persons who died in the Swiss Hepatitis C Cohort Study (<jats:styled-content style=\"fixed-case\">SCCS<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">SFSO<\/jats:styled-content> data showed that <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality more than doubled between 1995 and 2003, but has since stabilized at ~2.5\/100\u00a0000 person\u2010years. Since 2000, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality has been higher than <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related mortality and was about fivefold higher in 2014. <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related mortality remained low at ~0.5\/100\u00a0000 person\u2010years. Of 4556 persons in the <jats:styled-content style=\"fixed-case\">SCCS<\/jats:styled-content>, 421 have died and 86.2% could be linked to the death registry. According to the <jats:styled-content style=\"fixed-case\">SCCS<\/jats:styled-content>, 133 deaths were <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> was not mentioned on the <jats:styled-content style=\"fixed-case\">SFSO<\/jats:styled-content> death certificate of 45% of these (n\u00a0=\u00a060\/133). In conclusion, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality remained constant, possibly because quality of care was high, or because of under\u2010reporting or because mortality has not yet increased. However, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related mortality is now much higher than <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related mortality, and under\u2010reporting was common.<\/jats:p>","DOI":"10.1111\/jvh.12803","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T02:52:53Z","timestamp":1511232773000},"page":"152-160","source":"Crossref","is-referenced-by-count":23,"title":["Trends in hepatitis C\u2010related mortality in Switzerland"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-2789","authenticated-orcid":false,"given":"O.","family":"Keiser","sequence":"first","affiliation":[{"name":"Institute of Global Health University of Geneva  Geneva Switzerland"},{"name":"Institute of Social and Preventive Medicine University of Bern  Bern 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