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To estimate the value of productivity losses due to genotype 1 (<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>1) <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection in Hong Kong, Singapore, South Korea and Taiwan and to estimate the potential productivity gains associated with treating patients with ledipasvir\/sofosbuvir (<jats:styled-content style=\"fixed-case\">LDV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content>) therapy, an economic model was developed with a time horizon of 1\u00a0year. Hepatitis C virus patients entered the model at 12\u00a0weeks post\u2010treatment, having achieved or not achieved sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>). Absenteeism and presenteeism rates were taken from a pooled analysis of data from the <jats:styled-content style=\"fixed-case\">ION<\/jats:styled-content> 1\u20103 studies. These rates were converted into hours of lost productivity, multiplied by the average wage and applied to the total employed, adult <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>1 population in each country. Results were compared assuming no treatment, and assuming all patients were treated with <jats:styled-content style=\"fixed-case\">LDV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content>. Total productivity losses due to untreated <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> were: $11.3 million, $17.1\u00a0m, $146.0\u00a0m and $349.1\u00a0m in Hong Kong, Singapore, South Korea and Taiwan. <jats:styled-content style=\"fixed-case\">LDV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content> treatment resulted in economic gains of $4.5\u00a0m, $6.8\u00a0m, $58.7\u00a0m and $138\u00a0m, respectively. These gains were due to reduced presenteeism. The results were sensitive to changes in the prevalence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and the average wage. In conclusion, productivity losses due to untreated <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection represent a substantial economic burden. By instituting universal <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment with <jats:styled-content style=\"fixed-case\">LDV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content> (or other therapies with high <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> rates), productivity gains can be achieved.<\/jats:p>","DOI":"10.1111\/jvh.12808","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T19:24:48Z","timestamp":1508527488000},"page":"228-235","source":"Crossref","is-referenced-by-count":11,"title":["Impact of ledipasvir\/sofosbuvir on the work productivity of genotype 1 chronic hepatitis C patients in Asia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Z. 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H.","family":"Lee","sequence":"additional","affiliation":[{"name":"National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-577X","authenticated-orcid":false,"given":"Y. \u2010S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Centre University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kruger","sequence":"additional","affiliation":[{"name":"IMS Health  Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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