{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:34:19Z","timestamp":1774852459778,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30800972"],"award-info":[{"award-number":["30800972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371876"],"award-info":[{"award-number":["81371876"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immunization with the hepatitis B vaccine is the most effective measure to prevent Hepatitis B Virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) infection. The aim of this study was to investigate the change in antibody levels induced by administration of the hepatitis B vaccine in children aged 1\u201016\u00a0year old in a large sample sized investigation. <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> markers were determined in 93\u00a0326 1\u2010 to 16\u2010year\u2010old hospitalized children who completed primary immunization as infants from south\u2010west China, Chongqing. Analyses were performed on anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s titre changes with increasing age, and the revaccination effect was evaluated in children aged 7\u201014. The percentage of protective antibody was between 45.29% and 63.33% in all age groups, but was higher in the 1\u2010, 2\u2010 and 3\u2010year\u2010old groups (90.31%, 83.95% and 71.82%, respectively), and the rate of high\u2010responder was 5.03%\u201010.56%, except in the 1\u2010year\u2010old group (23.33%). Additionally, 3.33%\u201025.79% of subjects had not seroconverted. There was no significant difference in antibody levels between girls and boys (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). The Geometric Mean Titers in children with confirmed revaccination history were significantly higher than those with unknown or no revaccination history (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). In conclusion, the overall rate of protective anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s was 67.10% with consecutive age groups from 1 to 16, it decreased from 90.31% to 45.29% for 1\u2010 to 8\u2010year\u2010old individuals, and interestingly, the rate increased from 45.46% to 63.33% for subjects aged 9\u201015. Anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>s titres were significantly improved after revaccination. Booster doses are recommended for those without seroconversion, especially children who live in school with other students or have family members with positive <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg.<\/jats:p>","DOI":"10.1111\/jvh.12818","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T14:42:34Z","timestamp":1509547354000},"page":"373-380","source":"Crossref","is-referenced-by-count":16,"title":["Changes and analysis of anti\u2010<scp>HB<\/scp>s titres after primary immunization in 1\u2010 to 16\u2010year\u2010old Chinese children: A hospital\u2010based study"],"prefix":"10.1111","volume":"25","author":[{"given":"X.","family":"Yue","sequence":"first","affiliation":[{"name":"Pediatric Research Institute Chongqing Key Laboratory of Child Infection and Immunity Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ge","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute Chongqing Key Laboratory of Child Infection and Immunity Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zhuge","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute Chongqing Key Laboratory of Child Infection and Immunity Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"He","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute Chongqing Key Laboratory of Child Infection and Immunity Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute Chongqing Key Laboratory of Child Infection and Immunity Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Xu","sequence":"additional","affiliation":[{"name":"Infection Department of the Children's Hospital Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis Department of Infectious Diseases The Second Affiliated Hospital Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-9436","authenticated-orcid":false,"given":"Y.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute Chongqing Key Laboratory of Child Infection and Immunity Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"405","article-title":"Hepatitis B vaccines: WHO position paper","volume":"84","author":"World Health Organization (WHO)","year":"2009","journal-title":"Wkly Epidemiol 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