{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:22:23Z","timestamp":1764332543947,"version":"3.37.3"},"reference-count":82,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To examine mid\u2010term benefits on hepatic complications, extrahepatic clinical syndromes and quality of life associated with HCV cure; to review the few safety issues linked to oral direct\u2010acting antivirals (DAAs); and to discuss the potential population benefits of reducing the burden of HCV infection. DAAs cure HCV infection in more than 95% of patients. The halting of liver inflammation and fibrosis progression translates into both hepatic and extrahepatic benefits and reduces the need for liver transplantation. A reduction in the frequency of extrahepatic manifestations such as mixed cryoglobulinaemia and vasculitis and improvements in quality of life and fatigue have also been described. A few safety issues linked to DAAs such as the potential recurrence of aggressive HCC, the flares of hepatitis B virus in patients with overt or occult HBV infection are been discussed. Curing HCV infection also has a high potential to reduce the burden of HCV infection at the population level. With widespread scaling up of HCV treatment, several modeling studies suggest that major reductions in HCV prevalence and incidence are possible, and that elimination of viral hepatitis is an achievable target by 2030.<\/jats:p>","DOI":"10.1111\/jvh.12823","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T14:04:09Z","timestamp":1510063449000},"page":"320-328","source":"Crossref","is-referenced-by-count":10,"title":["The benefits of hepatitis C virus cure: Every rose has thorns"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-8951","authenticated-orcid":false,"given":"D.","family":"Salmon","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Immunology Center for Diagnosis Paris Centre University Hospitals APHP, Paris Descartes University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. U.","family":"Mondelli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Maticic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Clinic for Infectious Diseases and Febrile Illnesses University Medical Centre Ljubljana University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Arends","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Infectious diseases section University Medical Center Utrecht (UMCU)  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The ESCMID Study Group for Viral Hepatitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.05.027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i44.7852"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ396"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12338"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28535"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27743"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.10.017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.009"},{"key":"e_1_2_8_11_1","unstructured":"SalmonD GilbertC SogniP et\u00a0al.Residual risk of disease progression after hepatitis C cure in HIV\u2010HCV patients. Conference on Retroviruses and Opportunistic Infections (CROI)2016;605: February 22\u201025 2016 Boston Massachusetts."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw362"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(16)00182-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.12.027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28923"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25606"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000787"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0606-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.015"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.004"},{"issue":"1231","key":"e_1_2_8_24_1","first-page":"1239","article-title":"Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C","volume":"141","author":"Ahlenstiel G","year":"2011","journal-title":"Gastroenterology"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179096"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13357"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.045"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13452"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i40.14559"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.2335"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204241200"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.025"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20944"},{"issue":"1","key":"e_1_2_8_36_1","first-page":"38","article-title":"The interaction between hepatitis B virus and hepatitis C virus in acute and chronic liver disease","volume":"22","author":"Alberti A","year":"1995","journal-title":"J Hepatol"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ474"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12754"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14177"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29109"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.10.011"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.035"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308163"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2684"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2015.1021660"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13465"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27623"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208339"},{"key":"e_1_2_8_49_1","article-title":"Treatment with direct\u2010acting antiviral agents is associated with improvement of renal function in a cohort of hepatitis C virus infected patients with chronic kidney disease","author":"Masetti C","year":"2017","journal-title":"International Liver Congress TM"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.90"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.007"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12136"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2016-000343"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520500325952"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9708-x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20659"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.02.042"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-017-0742-3"},{"key":"e_1_2_8_59_1","first-page":"Doc05","article-title":"Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals","volume":"6","author":"Prud'homme S","year":"2016","journal-title":"GMS Ophthalmol Cases"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.09.031"},{"key":"e_1_2_8_61_1","unstructured":"World Health Organization.Guidelines for the screening care and treatment of persons with hepatitis C infection.2016.http:\/\/apps.who.int\/iris\/bitstream\/10665\/205035\/1\/9789241549615_eng.pdf?ua=1."},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.144878"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0748-8"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2012.681332"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.09.001"},{"key":"e_1_2_8_66_1","unstructured":"World Health Organization.Global hepatitis report.2017.http:\/\/apps.who.int\/iris\/bitstream\/10665\/255016\/1\/9789241565455-eng.pdf?ua=1."},{"key":"e_1_2_8_67_1","unstructured":"European Liver Patients Association (ELPA).The 2016 Hep\u2010CORE Report.2016.http:\/\/www.elpa.eu\/sites\/default\/files\/project-documents\/Hep-CORE_full_report_21Mar2017_errata_Final.pdf."},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.01.024"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000179"},{"key":"e_1_2_8_70_1","unstructured":"BoerekampsA van denBerkGEL LauwF et\u00a0al.Substantial decline in acute HCV infections among Dutch HIV+MSM after DAA roll out. Conference on Retroviruses and Opportunistic Infections (CROI)2017;137LB: February 13\u201016 2017. Seattle Washington."},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.09.023"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12415"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0816"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw580"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.012"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit296"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41124-016-0011-y"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.02.007"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13521"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13783"},{"key":"e_1_2_8_81_1","unstructured":"World Health Organization.Global health sector strategy on viral hepatitis2016\u20132021http:\/\/apps.who.int\/iris\/bitstream\/10665\/246177\/1\/who-hiv-2016.06-eng.pdf?ua=1."},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12474"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30045-6"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:02:53Z","timestamp":1695542573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,19]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/jvh.12823"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12823","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"type":"print","value":"1352-0504"},{"type":"electronic","value":"1365-2893"}],"subject":[],"published":{"date-parts":[[2018,2,19]]}}}