{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:17:17Z","timestamp":1770895037322,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["NHC\u2010142832"],"award-info":[{"award-number":["NHC\u2010142832"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic hepatitis C (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) is a leading cause of hepatic fibrosis and cirrhosis. The level of fibrosis is traditionally established by histology, and prognosis is estimated using fibrosis progression rates (<jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>s; annual probability of progressing across histological stages). However, newer noninvasive alternatives are quickly replacing biopsy. One alternative, transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>), quantifies fibrosis by measuring liver stiffness (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>). Given these developments, the purpose of this study was (i) to estimate prognosis in treatment\u2010na\u00efve<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>patients using<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>\u2010based liver stiffness progression rates (<jats:styled-content style=\"fixed-case\">LSPR<\/jats:styled-content>) as an alternative to<jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>s and (ii) to compare consistency between<jats:styled-content style=\"fixed-case\">LSPR<\/jats:styled-content>s and<jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>s. A systematic literature search was performed using multiple databases (January 1990 to February 2016).<jats:styled-content style=\"fixed-case\">LSPR<\/jats:styled-content>s were calculated using either a direct method (given the difference in serial<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>s and time elapsed) or an indirect method given a single LSM and the estimated duration of infection and pooled using random\u2010effects meta\u2010analyses. For validation purposes, FPRs were also estimated. Heterogeneity was explored by random\u2010effects meta\u2010regression. Twenty\u2010seven studies reporting on 39 groups of patients (N\u00a0=\u00a05874) were identified with 35 groups allowing for indirect and 8 for direct estimation of<jats:styled-content style=\"fixed-case\">LSPR<\/jats:styled-content>. The majority (~58%) of patients were<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010coinfected. The estimated time\u2010to\u2010cirrhosis based on<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>vs biopsy was 39 and 38\u00a0years, respectively. In univariate meta\u2010regressions, male sex and<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>were positively and age at assessment, negatively associated with<jats:styled-content style=\"fixed-case\">LSPR<\/jats:styled-content>s. Noninvasive prognosis of<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>is consistent with<jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>s in predicting time\u2010to\u2010cirrhosis, but more longitudinal studies of liver stiffness are needed to obtain refined estimates.<\/jats:p>","DOI":"10.1111\/jvh.12846","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T07:12:41Z","timestamp":1513235561000},"page":"502-513","source":"Crossref","is-referenced-by-count":32,"title":["Estimating chronic hepatitis C prognosis using transient elastography\u2010based liver stiffness: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-3497","authenticated-orcid":false,"given":"A.","family":"Erman","sequence":"first","affiliation":[{"name":"Leslie Dan Faculty of Pharmacy University of Toronto Toronto ON Canada"},{"name":"Toronto Health Economics and Technology Assessment Collaborative (THETA) University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sathya","sequence":"additional","affiliation":[{"name":"School of Medicine Queen's University Kingston ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nam","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management, and Evaluation University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Bielecki","sequence":"additional","affiliation":[{"name":"Toronto Health Economics and Technology Assessment Collaborative (THETA) University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Feld","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease Sandra Rotman Centre for Global Health University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u2010H.","family":"Thein","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. W. 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