{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:28:50Z","timestamp":1790674130011,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In Egypt, hepatocellular carcinoma (HCC) is the most common form of cancer and direct\u2010acting antivirals (DAA) are administered on a large scale to patients with chronic HCV infection to reduce the risk. In this unique setting, we aimed to determine the association of DAA exposure with early\u2010phase HCC recurrence in patients with a history of HCV\u2010related liver cancer. This was a prospective cohort study of an HCV\u2010infected population from one Egyptian specialized HCC management centre starting from the time of successful HCC intervention. The incidence rates of HCC recurrence between DAA\u2010exposed and nonexposed patients were compared, starting from date of HCC complete radiological response and censoring after 2\u00a0years. DAA exposure was treated as time varying. Two Poisson regressions models were used to control for potential differences in the exposed and nonexposed group; multivariable adjustment and balancing using inverse probability of treatment weighting (IPTW). We included 116 patients: 53 treated with DAAs and 63 not treated with DAAs. There was 37.7% and 25.4% recurrence in each group after a median of 16.0 and 23.0\u00a0months of follow\u2010up, respectively. Poisson regression using IPTW demonstrated an association between DAAs and HCC recurrence with an incidence rate ratio of 3.83 (95% CI: 2.02\u20107.25), which was similar in the multivariable\u2010adjusted model and various sensitivity analyses. These results add important evidence towards the possible role of DAAs in HCC recurrence and stress the need for further mechanistic studies and clinical trials to accurately confirm this role and to identify patient characteristics that may be associated with this event.<\/jats:p>","DOI":"10.1111\/jvh.12854","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T10:38:28Z","timestamp":1514111908000},"page":"623-630","source":"Crossref","is-referenced-by-count":78,"title":["Increased recurrence rates of hepatocellular carcinoma after DAA therapy in a hepatitis C\u2010infected Egyptian cohort: A comparative analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-6894","authenticated-orcid":false,"given":"M.","family":"El Kassas","sequence":"first","affiliation":[{"name":"Endemic Medicine Department Faculty of Medicine Helwan University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2440-7553","authenticated-orcid":false,"given":"A. L.","family":"Funk","sequence":"additional","affiliation":[{"name":"Emerging Disease Epidemiology Unit Institut Pasteur  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salaheldin","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Shimakawa","sequence":"additional","affiliation":[{"name":"Emerging Disease Epidemiology Unit Institut Pasteur  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eltabbakh","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jean","sequence":"additional","affiliation":[{"name":"Laboratoire MESuRS (EA 4628) Conservatoire National Des Arts et M\u00e9tiers  Paris France"},{"name":"Unit\u00e9 PACRI Institut Pasteur, Conservatoire National des Arts et M\u00e9tiers  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"El Tahan","sequence":"additional","affiliation":[{"name":"New Cairo Viral Hepatitis Treatment Unit  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Sweedy","sequence":"additional","affiliation":[{"name":"New Cairo Viral Hepatitis Treatment Unit  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Afify","sequence":"additional","affiliation":[{"name":"National Hepatology and Tropical Medicine Research Institute  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. F.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Medical Surgical Nursing Department Faculty of Nursing Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Esmat","sequence":"additional","affiliation":[{"name":"Endemic Medicine and Hepato\u2010Gastroenterology Department Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fontanet","sequence":"additional","affiliation":[{"name":"Emerging Disease Epidemiology Unit Institut Pasteur  Paris France"},{"name":"Unit\u00e9 PACRI Institut Pasteur, Conservatoire National des Arts et M\u00e9tiers  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-5-201303050-00005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290439"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.08.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.045"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13321"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601349"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/437971"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13186"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12668"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82626-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.034"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5984"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v043.i13"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6607"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167934"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu066"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00360-4"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:34:51Z","timestamp":1695490491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/jvh.12854"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12854","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,24]]}}}