{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:59:41Z","timestamp":1789819181548,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["30\u20102016\u20100190"],"award-info":[{"award-number":["30\u20102016\u20100190"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>Nucleos(t)ide analogues (NA<\/jats:styled-content>s) have been shown to decrease the risk of hepatocellular carcinoma (HCC<\/jats:styled-content>) recurrence. This study evaluated whether high\u2010potency NA<\/jats:styled-content>s (entecavir and tenofovir disoproxil fumarate [TDF<\/jats:styled-content>]) reduce the risk of tumour recurrence more potently than low\u2010potency NA<\/jats:styled-content>s after curative treatment of hepatitis B virus (HBV<\/jats:styled-content>)\u2010related HCC<\/jats:styled-content>. This study included 607 consecutive HBV<\/jats:styled-content>\u2010related HCC<\/jats:styled-content> patients treated with surgical resection or radiofrequency ablation. The patients were categorized into three groups according to antiviral treatment: group A (no antiviral; n\u00a0=\u00a0261), group B (low\u2010potency NA<\/jats:styled-content>; n\u00a0=\u00a090) and group C (high\u2010potency NA<\/jats:styled-content>; n\u00a0=\u00a0256). The primary end\u2010point was recurrence\u2010free survival (RFS<\/jats:styled-content>). During the duration of follow\u2010up, the median RFS<\/jats:styled-content> was 29.4, 25.1, and 88.2\u00a0months in groups A, B and C, respectively (P<\/jats:italic>\u00a0<\u00a0.001, log\u2010rank test). The multivariate Cox analysis indicated that group C had a significantly longer RFS<\/jats:styled-content> than both group A (adjusted hazard ratio [HR<\/jats:styled-content>]\u00a0=\u00a00.39, P<\/jats:italic>\u00a0<\u00a0.001) and group B (adjusted HR<\/jats:styled-content>\u00a0=\u00a00.47, P<\/jats:italic>\u00a0<\u00a0.001). When baseline characteristics were balanced using inverse probability weighting, group C still had a significantly longer RFS<\/jats:styled-content> than group A (adjusted HR<\/jats:styled-content>\u00a0=\u00a00.46, P<\/jats:italic>\u00a0<\u00a0.001) and group B (adjusted HR<\/jats:styled-content>\u00a0=\u00a00.59, P<\/jats:italic>\u00a0=\u00a0.007). Group C had significantly lower risk of viral breakthrough than group B (HR<\/jats:styled-content>\u00a0=\u00a00.19, P<\/jats:italic>\u00a0<\u00a0.001). Viral breakthrough was an independent risk factor for shorter RFS<\/jats:styled-content> among groups B and C (adjusted HR<\/jats:styled-content>\u00a0=\u00a02.03, P<\/jats:italic>\u00a0=\u00a0.007, time\u2010dependent Cox analysis). Antiviral agents with high genetic barrier to resistance (entecavir and TDF<\/jats:styled-content>) reduced the risk of HCC<\/jats:styled-content> recurrence compared with other antivirals and no antiviral treatment, especially in patients with high baseline viral load.<\/jats:p>","DOI":"10.1111\/jvh.12855","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T03:36:51Z","timestamp":1515555411000},"page":"707-717","source":"Crossref","is-referenced-by-count":26,"title":["Entecavir and tenofovir reduce hepatitis B virus\u2010related hepatocellular carcinoma recurrence more effectively than other antivirals"],"prefix":"10.1111","volume":"25","author":[{"given":"H.","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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