{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:37:10Z","timestamp":1761863830361,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Polskie Towarzystwo Epidemiolog\u00f3w i Lekarzy Chor\u00f3b Zaka\u017anych"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of the EpiTer\u20102 study was to analyse patient characteristics and their medication for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection in Poland at the beginning of the interferon\u2010free era. Analysis of data of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infected patients treated during the initial period of availability of interferon\u2010free regimens in Poland, who started therapy after 1 July 2015 and had available an efficacy evaluation report before 30 June 2017 was undertaken. A total of 2879 patients with chronic hepatitis C were entered, including 46% with liver cirrhosis. The most common was genotype 1b (86.8%). The study population was gender balanced, the majority of patients were overweight or obese and 69% presented comorbidities, with the highest prevalence that for hypertension. More than half of patients were retreated due to failure of previous therapy with pegylated interferon and ribavirin. Almost two\u2010third of patients received current therapy with ombitasvir\/paritaprevir\/ritonavir\u00b1dasabuvir (<jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>rD) \u00b1ribavirin. Other patients received mostly sofosbuvir\u2010based regimens including combination with ledipasvir and pegylated interferon and ribavirin for genotype 3\u2010infected patients. Efficacy of treatment in the whole study population measured as intent\u2010to\u2010treat analysis was 95%. The most frequent regimen, administered for patients infected with genotype 1b, was 12\u00a0weeks of <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>rD, resulting in an <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> rate of 98%. At least one adverse event was reported in 38% of patients, and the death rate was 0.8%. <jats:bold>In conclusion,<\/jats:bold> data from the EpiTer\u20102 study confirmed the excellent efficacy and safety profile of the real\u2010world experience with recently introduced therapeutic options for genotype 1 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection, but demonstrated weakness of the current therapeutic programme regarding genotype 3 infections.<\/jats:p>","DOI":"10.1111\/jvh.12861","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T03:54:38Z","timestamp":1515556478000},"page":"661-669","source":"Crossref","is-referenced-by-count":19,"title":["Treatment of <scp>HCV<\/scp> infection in Poland at the beginning of the interferon\u2010free era\u2014the EpiTer\u20102 study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-1635","authenticated-orcid":false,"given":"R.","family":"Flisiak","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zar\u0119bska\u2010Michaluk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Voivodship Hospital and Jan Kochanowski University  Kielce Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Janczewska","sequence":"additional","affiliation":[{"name":"Hepatology Outpatient Clinic ID Clinic  Mys\u0142owice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Staniaszek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry 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Hepatology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Belica\u2010Wdowik","sequence":"additional","affiliation":[{"name":"Regional Center for Diagnosis and Treatment of Viral Hepatitis and Hepatology John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Baka\u2010\u0106wierz","sequence":"additional","affiliation":[{"name":"Regional Center for Diagnosis and Treatment of Viral Hepatitis and Hepatology John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dybowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Faculty of Medicine Collegium Medicum Bydgoszcz Nicolaus Copernicus University Toru\u0144  Toru\u0144 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