{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:09:56Z","timestamp":1783973396310,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K01532X\/1"],"award-info":[{"award-number":["MR\/K01532X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hepatitis C virus (HCV)\u2010infected patients are at risk of developing hepatocellular carcinoma (HCC). Individuals at heightened risk could be targeted by intensive follow\u2010up surveillance. We have conducted a systematic review of the literature to identify host genetic predisposition to HCC in HCV\u2010infected patients. A comprehensive search of Medline and Embase databases was performed, and the strength of evidence of associations for each gene on development of HCC was evaluated. We identified 166 relevant studies, relating to 137 different genes, or combinations thereof. Seventeen genes were classified as having \u201cgood\u201d evidence of an association, a significant association was observed for 37 genes but this finding had not yet been replicated, 56 genes had mixed or limited evidence of an association, and 27 genes showed no association. <jats:italic>IFNL3<\/jats:italic><jats:styled-content><jats:italic>\/4<\/jats:italic><\/jats:styled-content>, <jats:italic>TNF\u2010<\/jats:italic>\u03b1 and <jats:italic>PNPLA3<\/jats:italic> genes had the most evidence of an association. There was, however, considerable heterogeneity in study design and data quality. In conclusion, we identified a number of genes with evidence of association with HCC, but also a need for more standardized approaches to address this clinically critical question. It is important to consider the underlying mechanism of these relationships and which are confounded by the presence of other HCC risk factors and response to therapy. We also identified many genes where the evidence of association is contradictory or requires replication, as well as a number where associations have been studied but no evidence found. These findings should help to direct future studies on host genetic predisposition to HCC in HCV\u2010infected patients.<\/jats:p>","DOI":"10.1111\/jvh.12871","type":"journal-article","created":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T14:46:35Z","timestamp":1517669195000},"page":"442-456","source":"Crossref","is-referenced-by-count":19,"title":["Host genetic factors associated with hepatocellular carcinoma in patients with hepatitis C virus infection: A systematic review"],"prefix":"10.1111","volume":"25","author":[{"given":"A. 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J.","family":"Peacock","sequence":"additional","affiliation":[{"name":"National Institute for Health research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Pedergnana","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"STOP\u2010HCV Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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