{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:47:27Z","timestamp":1773370047161,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Liver Institute, Menofiya University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fulminant hepatic failure is a life\u2010threatening disease. Hepatitis A virus (<jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content>) can cause fulminant hepatic failure and death in about 0.2% of cases. Extensive destruction of infected hepatocytes by immune\u2010mediated lysis is thought to be the cause. We aimed to evaluate the use of steroid therapy in children with fulminant <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content>. This study included 33 children with fulminant <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> in two groups. Steroid group: comprised of 18 children who received prednisolone (1\u00a0mg\/kg\/d) or its equivalent dose of methylprednisolone, and the nonsteroid group: comprised another 15 children who did not receive steroid therapy. Age and sex were matched for both groups (<jats:italic>P\u00a0&gt;\u00a0<\/jats:italic>.05), and they were comparable regarding baseline clinical and laboratory characteristics. Of the steroid group, 15 patients survived and 3 died, while in the nonsteroid group, 4 patients survived and 11 died (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.001). Of the living patients, 15 of 19 (78.9%) received steroids while only 3 of 14 (21.4%) of the dead patients received steroids (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.001). Stepwise regression analysis showed that steroid therapy was the only independent variable associated with recovery (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.001). Steroid therapy in children with fulminant <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> associated significantly with improved outcome and survival. Future studies on a larger population size are strongly recommended.<\/jats:p>","DOI":"10.1111\/jvh.12873","type":"journal-article","created":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T14:56:41Z","timestamp":1517669801000},"page":"853-859","source":"Crossref","is-referenced-by-count":9,"title":["Steroid therapy in children with fulminant hepatitis A"],"prefix":"10.1111","volume":"25","author":[{"given":"H. M.","family":"Zakaria","sequence":"first","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"},{"name":"Department of Pediatrics Quesna Central Hospital Ministry of Health  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. A.","family":"Salem","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"El\u2010Araby","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Salama","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Y.","family":"Elbadry","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-4012","authenticated-orcid":false,"given":"A. M.","family":"Sira","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Salem","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Abd\u2010Alaaty","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology, Gastroenterology and Nutrition Department National Liver Institute Menofiya University  Menofiya Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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