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Based on the percentage of nucleotide identity of the genome,<jats:styled-content style=\"fixed-case\">HDV<\/jats:styled-content>was initially classified into three genotypes. However, since 2006, the original classification has been further expanded into eight clades\/genotypes. The intergenotype divergence may be as high as 35%\u201040% over the entire<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>genome, whereas sequence heterogeneity among the isolates of a given genotype is &lt;20%; furthermore,<jats:styled-content style=\"fixed-case\">HDV<\/jats:styled-content>recombinants have been clearly demonstrated. The genetic diversity of<jats:styled-content style=\"fixed-case\">HDV<\/jats:styled-content>is related to the geographic origin of the isolates. This study shows the first comprehensive bioinformatic analysis of the complete available set of<jats:styled-content style=\"fixed-case\">HDV<\/jats:styled-content>sequences, using both nucleotide and protein phylogenies (based on an evolutionary model selection, gamma distribution estimation, tree inference and phylogenetic distance estimation), protein composition analysis and comparison (based on the presence of invariant residues, molecular signatures, amino acid frequencies and mono\u2010 and di\u2010amino acid compositional distances), as well as amino acid changes in sequence evolution. Taking into account the congruent and consistent results of both nucleotide and amino acid analyses of GenBank available sequences (recorded as of January, 2017), we propose that the eight hepatitis D virus genotypes may be grouped into three large genogroups fully supported by their shared characteristics.<\/jats:p>","DOI":"10.1111\/jvh.12876","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T15:22:36Z","timestamp":1517930556000},"page":"860-869","source":"Crossref","is-referenced-by-count":12,"title":["A comprehensive bioinformatic analysis of hepatitis D virus full\u2010length genomes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-193X","authenticated-orcid":false,"given":"C. 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