{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:54:48Z","timestamp":1778291688462,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Data regarding the impact of hepatitis C (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) therapy on incidence of type 2 diabetes mellitus are limited. We used the data from the longitudinal Chronic Hepatitis Cohort Study\u2014drawn from four large <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> health systems\u2014to investigate how response to <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment impacts the risk of subsequent diabetes. Among HCV patients without a history of type 2 diabetes mellitus or hepatitis B, we investigated the incidence of type 2 diabetes from 12 weeks post\u2010HCV treatment through December 2015. Cox proportional hazards models were used to test the effect of treatment status (sustained virologic response [SVR] or treatment failure) and baseline risk factors on the development of diabetes, considering any possible risk factor\u2010by\u2010SVR interactions, and death as a competing risk. Among 5127 patients with an average follow\u2010up of 3.7 years, diabetes incidence was significantly lower among patients who achieved SVR (231\/3748; 6.2%) than among patients with treatment failure (299\/1379; 21.7%; adjusted hazard ratio [aHR] = 0.79; 95% CI: 0.65\u20100.96). Risk of diabetes was higher among African American and Asian American patients than White patients (aHR = 1.82 and 1.75, respectively; <jats:italic>P<\/jats:italic> &lt; .05), and among Hispanic patients than non\u2010Hispanics (aHR = 1.86). Patients with BMI \u2265 30 and 25\u201030 (demonstrated higher risk of diabetes aHR = 3.62 and 1.72, respectively; <jats:italic>P<\/jats:italic> &lt; .05) than those with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u00a0&lt;\u00a025; patients with cirrhosis at baseline had higher risk than those without cirrhosis (<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>\u00a0=\u00a01.47). Among a large <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> cohort of patients treated for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, patients who achieved <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> demonstrated a substantially lower risk for the development of type 2 diabetes mellitus than patients with treatment failure.<\/jats:p>","DOI":"10.1111\/jvh.12887","type":"journal-article","created":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T07:02:34Z","timestamp":1519542154000},"page":"952-958","source":"Crossref","is-referenced-by-count":26,"title":["Impact of sustained virologic response on risk of type 2 diabetes among hepatitis C patients in the United States"],"prefix":"10.1111","volume":"25","author":[{"given":"J.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Rupp","sequence":"additional","affiliation":[{"name":"Center for Health Policy and Health Services Research Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1280-0833","authenticated-orcid":false,"given":"S.","family":"Trudeau","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Moorman","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"Spradling","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. H.","family":"Teshale","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-6805","authenticated-orcid":false,"given":"J. A.","family":"Boscarino","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Services Research Geisinger Clinic  Danville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Center for Health Research Kaiser Permanente\u2013Northwest  Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. G.","family":"Daida","sequence":"additional","affiliation":[{"name":"Center for Health Research Kaiser Permanente\u2013Hawaii  Honolulu HI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the CHeCS Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22703"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0456"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25867"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02002.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis815"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2016.12.088"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12224"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2015.00134"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0421-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2016.11.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27047"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50291"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm061"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13194"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.90"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27252"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.12.017"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0683-2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02343.x"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T01:04:13Z","timestamp":1694999053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,15]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/jvh.12887"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12887","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,15]]}}}