{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:14:27Z","timestamp":1790705667412,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005258","name":"National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005258","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hepatitis E virus (<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>) genotype (gt) 3 infection is food\u2010borne causing sporadic infections in older individuals and gt1 infection is waterborne, often causing epidemics affecting primarily young adults. Although <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> infection causes self\u2010limited disease, gt3 induces chronic infection in immunocompromised individuals. Hepatic host gene expression against gt3 infection remains unknown. Host gene expression profiles for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> gt1 (n\u00a0=\u00a03) and gt3 (n\u00a0=\u00a07) infections were analysed in the livers of experimentally infected rhesus macaques. <jats:styled-content style=\"fixed-case\">HEV RNA<\/jats:styled-content> was detected from 2 to 24\u00a0days after inoculation (<jats:styled-content style=\"fixed-case\">DAI<\/jats:styled-content>) in stool and serum, elevated alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) activity was detected from 7 to 31 <jats:styled-content style=\"fixed-case\">DAI<\/jats:styled-content>, and anti\u2010<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> antibody became detectable between 12 and 42 <jats:styled-content style=\"fixed-case\">DAI<\/jats:styled-content>. All 10 animals cleared the infection between 34 and 68 <jats:styled-content style=\"fixed-case\">DAI<\/jats:styled-content>. We found that 24%, 48% and 41% of hepatic immune response genes against gt3 infection were upregulated during the early, peak and decline phases of <jats:styled-content style=\"fixed-case\">HEV RNA<\/jats:styled-content> replication. For gt1 infection, 25% of hepatic immune response\u2010related genes were downregulated during early viremia, but 6%, 34% and 37% of genes were upregulated at the early, peak and during decline of <jats:styled-content style=\"fixed-case\">HEV RNA<\/jats:styled-content> replication, respectively. Our study demonstrated distinct differences in the expression profiles of host immune response\u2010related genes of <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> gt3 and gt1 infections in experimentally infected rhesus macaques.<\/jats:p>","DOI":"10.1111\/jvh.12890","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:31:40Z","timestamp":1521109900000},"page":"986-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Expression profiles of host immune response\u2010related genes against <scp>HEV<\/scp> genotype 3 and genotype 1 infections in rhesus macaques"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5146-6121","authenticated-orcid":false,"given":"Y. 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