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However, the results remain inconsistent and somehow conflicting in different subgroups. The aim of this study was to combine the findings of independent studies to comprehensively assess the association between HBV<\/jats:styled-content> and NHL<\/jats:styled-content> using a meta\u2010analysis. Relevant studies were identified through structured keyword searches in PubMed, EMBASE<\/jats:styled-content> and the China National Knowledge Infrastructure (CNKI<\/jats:styled-content>) database, and 58 studies with a total of 53\u00a0714 NHL<\/jats:styled-content> cases and 1\u00a0778\u00a0591 controls were finally included. Pooled estimates indicated a significantly increased NHL<\/jats:styled-content> risk in HBV<\/jats:styled-content>\u2010infected individuals (summary odds ratio [sOR<\/jats:styled-content>]: 2.50; 95% confidence interval [CI<\/jats:styled-content>]: 2.20\u20102.83) regardless of the study design (case\u2013control studies: sOR<\/jats:styled-content>: 2.47; 95% CI<\/jats:styled-content>: 2.16\u20102.82; cohort studies: sOR<\/jats:styled-content>: 2.64; 95% CI<\/jats:styled-content>: 1.78\u20103.91). Considerable heterogeneity was observed across studies that was primarily attributed to the NHL<\/jats:styled-content> subtypes (meta\u2010regression: P<\/jats:italic>\u00a0<\u00a0.05). Overall, B\u2010cell NHL<\/jats:styled-content> (sOR<\/jats:styled-content>: 2.46; 95% CI<\/jats:styled-content>: 1.97\u20103.07) presented a stronger association with HBV<\/jats:styled-content> infection than T\u2010cell NHL<\/jats:styled-content> (sOR<\/jats:styled-content>: 1.67; 95% CI<\/jats:styled-content>: 1.34\u20102.10). Within the B\u2010cell NHL<\/jats:styled-content> subtypes, HBV<\/jats:styled-content> infection was significantly associated with diffuse large B\u2010cell lymphoma (DLBCL<\/jats:styled-content>, sOR<\/jats:styled-content>: 2.06; 95% CI<\/jats:styled-content>: 1.48\u20102.88) and follicular lymphoma (FL<\/jats:styled-content>, sOR<\/jats:styled-content>: 1.54; 95% CI<\/jats:styled-content>: 1.11\u20102.12), but not with chronic lymphocytic leukaemia\/small lymphocytic lymphoma (CLL<\/jats:styled-content>\/SLL<\/jats:styled-content>) and Burkitt lymphoma. The results of this meta\u2010analysis support a positive link between HBV<\/jats:styled-content> infection and NHL<\/jats:styled-content> development. Further investigations for the mechanisms underlying HBV<\/jats:styled-content>\u2010induced NHL<\/jats:styled-content> are warranted.<\/jats:p>","DOI":"10.1111\/jvh.12892","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:31:41Z","timestamp":1521109901000},"page":"894-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Hepatitis B virus and risk of non\u2010Hodgkin lymphoma: An updated meta\u2010analysis of 58 studies"],"prefix":"10.1111","volume":"25","author":[{"given":"M.","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Etiology Qidong People's Hospital\/Qidong Liver Cancer Institute Qidong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Medical Insurance Affairs Management Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-5207","authenticated-orcid":false,"given":"H.","family":"Tu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890170111"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(98)00172-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61412-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00218-2"},{"key":"e_1_2_9_6_1","unstructured":"FerlayJ SoerjomataramI ErvikM et\u00a0al.GLOBOCAN 2012 v1.0 Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11. 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