{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:16:54Z","timestamp":1762431414826,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Catalan Agency for the Management of Grants for University Research","award":["AGAUR Grant number 2017\/SGR1342"],"award-info":[{"award-number":["AGAUR Grant number 2017\/SGR1342"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>At the end of 1998, universal hepatitis A+B vaccination of 12\u00a0year olds was introduced in Catalonia. The aim was to examine trends in hepatitis A during 2005\u20102015 and assess risk factors by age group. We carried out an observational epidemiological study of the incidence and risk factors of hepatitis A reported to the surveillance system. Information on exposure was recorded for each case for the 2\u20106\u00a0weeks before symptom onset. Spearman's coefficient was used to evaluate the trends of rates. The chi\u2010square test was used to compare categorical. We studied 2621 hepatitis A cases; the age mean was 26.6\u00a0years (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>=18.2), and &gt;50% of cases were in the 20\u201049\u00a0years age group. The incidence decreased from 3.28\/100\u00a0000 in 2005 to 1.50\/100\u00a0000 in 2015. The rate for women decreased over time (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008), but the reduction was not significant in men (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.234). Men consistently had higher rates than women with the biggest difference being in the 20\u201034\u00a0years age group (rate 8.8 vs 2.8). The greatest risk factor was travel to an endemic country (42.1%) in the 0\u201019\u00a0years age group and male\u2010to\u2010male sexual contact (18.6%) in the 20\u201049\u00a0years age group. The case fatality rate in adults aged &gt;49\u00a0years was 0.4%. In conclusion, the vaccination programme of preadolescents resulted in a reduction in hepatitis A cases. However, a significant amount of cases still appear in immigrants and men who have sex with men. Hepatitis A in adults is an emerging health problem that will require new strategies.<\/jats:p>","DOI":"10.1111\/jvh.12900","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T11:37:06Z","timestamp":1522496226000},"page":"1001-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Trends and risk factors of hepatitis A in Catalonia after the introduction of a hepatitis A+B vaccination programme"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-7286","authenticated-orcid":false,"given":"P.","family":"Godoy","sequence":"first","affiliation":[{"name":"Ag\u00e8ncia de Salut P\u00fablica de Catalunya Generalitat de Catalunya  Barcelona Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Barcelona Spain"},{"name":"Institut de Recerca Biom\u00e9dica de Lleida. 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