{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T07:08:02Z","timestamp":1720336082318},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with chronic hepatitis C who achieve a sustained viral response after pegylated interferon therapy have a reduced risk of hepatocellular carcinoma, but the risk after treatment with direct\u2010acting antivirals is unclear. We compared the rates of early development of hepatocellular carcinoma after direct\u2010acting antivirals and after pegylated interferon therapy. We retrospectively analysed 785 patients with chronic hepatitis C who had no history of hepatocellular carcinoma (211 treated with pegylated interferon, 574 with direct\u2010acting antivirals) and were followed up for at least 24\u00a0weeks after antiviral treatment. De novo hepatocellular carcinoma developed in 6 of 574 patients receiving direct\u2010acting antivirals and in 1 of 211 patients receiving pegylated interferon. The cumulative incidence of early hepatocellular carcinoma development did not differ between the treatment groups either for the whole cohort (1.05% vs 0.47%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.298) or for those patients with Child\u2010Pugh Class A cirrhosis (3.73% vs 2.94%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.827). Multivariate analysis indicated that alpha\u2010fetoprotein level &gt;9.5\u00a0ng\/mL at the time of end\u2010of\u2010treatment response was the only independent risk factor for early development of hepatocellular carcinoma in all patients (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.0001, hazard ratio 176.174, 95% confidence interval 10.768\u20102882.473) and in patients treated with direct\u2010acting agents (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.0001, hazard ratio 128.402, 95% confidence interval 8.417\u20101958.680). In conclusion, the rate of early development of hepatocellular carcinoma did not differ between patients treated with pegylated interferon and those treated with direct\u2010acting antivirals and was associated with the serum alpha\u2010fetoprotein level at the time of end\u2010of\u2010treatment response.<\/jats:p>","DOI":"10.1111\/jvh.12918","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T16:14:52Z","timestamp":1523895292000},"page":"1189-1196","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early development of de novo hepatocellular carcinoma after direct\u2010acting agent therapy: Comparison with pegylated interferon\u2010based therapy in chronic hepatitis C patients"],"prefix":"10.1111","volume":"25","author":[{"given":"S. H.","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Incheon St. Mary\u2019s Hospital The Catholic University of Korea  Incehon Korea"},{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Incheon St. Mary\u2019s Hospital The Catholic University of Korea  Incehon Korea"},{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Incheon St. Mary\u2019s Hospital The Catholic University of Korea  Incehon Korea"},{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Uijeongbu St. Mary\u2019s Hospital The Catholic University of Korea  Uijeongbu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Uijeongbu St. Mary\u2019s Hospital The Catholic University of Korea  Uijeongbu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"You","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine St. Paul\u2019s Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Choi","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine St. Paul\u2019s Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Cho","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Yeouido St. Mary\u2019s Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010Y.","family":"Han","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Yeouido St. Mary\u2019s Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Song","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine St. Vincent\u2019s Hospital The Catholic University of Korea  Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U. I.","family":"Chang","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine St. Vincent\u2019s Hospital The Catholic University of Korea  Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Yang","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine St. Vincent\u2019s Hospital The Catholic University of Korea  Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. L.","family":"Lee","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Bucheon St. Mary\u2019s Hospital The Catholic University of Korea  Bucheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Bucheon St. Mary\u2019s Hospital The Catholic University of Korea  Bucheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. I.","family":"Han","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Bucheon St. Mary\u2019s Hospital The Catholic University of Korea  Bucheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Daejeon St. Mary\u2019s Hospital The Catholic University of Korea  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Song","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Daejeon St. Mary\u2019s Hospital The Catholic University of Korea  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Catholic University Liver Research Center The Catholic University of Korea  Seoul Korea"},{"name":"Department of Internal Medicine Seoul St. Mary\u2019s Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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