{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:00:49Z","timestamp":1788490849841,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672025"],"award-info":[{"award-number":["81672025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702011"],"award-info":[{"award-number":["81702011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160121"],"award-info":[{"award-number":["BK20160121"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>Identifying the degree of liver inflammation is critical for therapeutic judgement of patients with chronic hepatitis B (CHB<\/jats:styled-content>). However, we lack indexes which can accurately predict significant liver inflammation in patients with CHB<\/jats:styled-content>. This study aimed to develop a simple predictive index for liver inflammation in CHB<\/jats:styled-content> using routine clinical parameters. A total of 519 patients with CHB<\/jats:styled-content> who underwent liver biopsy were enrolled and randomly divided into training (n\u00a0=\u00a0346) and validation cohorts (n\u00a0=\u00a0173). Based on routine clinical parameters, gamma\u2010glutamyl transpeptidase (GGT<\/jats:styled-content>; P<\/jats:italic>\u00a0=\u00a00.031) and platelets (PLT<\/jats:styled-content>; P<\/jats:italic>\u00a0<\u00a00.001) were identified as independent predictors of significant inflammation by multivariable analysis in the training cohort. Accordingly, the GGT<\/jats:styled-content> to PLT<\/jats:styled-content> ratio (GPR<\/jats:styled-content>) was developed to amplify the opposing effects for predicting liver inflammation. In the training cohort, the AUC<\/jats:styled-content>s of GPR<\/jats:styled-content> in predicting significant inflammation were 0.791 (95% CI<\/jats:styled-content>: 0.742\u20100.839), 0.783 (95% CI<\/jats:styled-content>: 0.717\u20100.849) and 0.791 (95% CI<\/jats:styled-content>: 0.716\u20100.867) in the entire patients with CHB<\/jats:styled-content>, HB<\/jats:styled-content>eAg\u2010positive CHB patients and HB<\/jats:styled-content>eAg\u2010negative CHB<\/jats:styled-content> patients, respectively. The diagnostic performance of GPR<\/jats:styled-content> for significant inflammation was significantly superior to that of alanine aminotransferase (ALT<\/jats:styled-content>), aspartate transaminase (AST<\/jats:styled-content>) and GGT<\/jats:styled-content> in all patients with CHB<\/jats:styled-content> and HB<\/jats:styled-content>eAg\u2010positive CHB<\/jats:styled-content> patients, but was comparable with ALT<\/jats:styled-content>, AST<\/jats:styled-content> and GGT<\/jats:styled-content> in HB<\/jats:styled-content>eAg\u2010negative CHB<\/jats:styled-content> patients. In the validation cohort, the diagnostic performance of GPR<\/jats:styled-content> in assessing significant liver inflammation was also superior to other indexes in all patients with CHB<\/jats:styled-content> and HB<\/jats:styled-content>eAg\u2010positive CHB patients, but was comparable with GGT<\/jats:styled-content> in HB<\/jats:styled-content>eAg\u2010negative CHB patients. Thus, GPR<\/jats:styled-content> can be a novel and simple index for predicting significant liver inflammation in CHB<\/jats:styled-content>, especially for HB<\/jats:styled-content>eAg\u2010positive CHB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.12925","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T10:59:27Z","timestamp":1525863567000},"page":"1151-1160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B"],"prefix":"10.1111","volume":"25","author":[{"given":"J.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu China"},{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College 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Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 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