{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T22:46:58Z","timestamp":1780786018535,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","award":["03\u20102016\u20100380"],"award-info":[{"award-number":["03\u20102016\u20100380"]}],"id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>Nucleot(s)ide analogues (NA<\/jats:styled-content>s) reduce the risk of hepatocellular carcinoma (HCC<\/jats:styled-content>) in chronic hepatitis B (CHB<\/jats:styled-content>) patients. However, the risk of HCC<\/jats:styled-content> is reportedly higher for NA<\/jats:styled-content>\u2010treated patients than for patients in the inactive CHB<\/jats:styled-content> phase. This study aimed to compare the long\u2010term outcomes of CHB<\/jats:styled-content> patients with NA<\/jats:styled-content>\u2010induced viral suppression and those of patients with inactive CHB<\/jats:styled-content>. This retrospective study involved 1118 consecutive CHB<\/jats:styled-content> patients whose HBV DNA<\/jats:styled-content> level was continuously <2000 IU<\/jats:styled-content>\/mL<\/jats:styled-content> during follow\u2010up with\/without antiviral agents. The patients were classified into inactive CHB<\/jats:styled-content> (n\u00a0=\u00a0373) or NA<\/jats:styled-content> groups (n\u00a0=\u00a0745). The primary endpoint was overall survival. Secondary endpoints included development of HCC<\/jats:styled-content> and other liver\u2010related events. The median duration of follow\u2010up was 41.0 (interquartile range = 26.5\u201055.0) months. The difference in overall survival between the NA<\/jats:styled-content> group vs. the inactive CHB<\/jats:styled-content> group was not significant (hazard ratio [HR<\/jats:styled-content>] = 0.78; 95% confidence interval [CI<\/jats:styled-content>] = 0.33\u20101.85; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.57). The NA<\/jats:styled-content> group showed a significantly higher risk of HCC<\/jats:styled-content> (HR<\/jats:styled-content> = 3.44; 95% CI<\/jats:styled-content> = 1.82\u20106.52; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01), but comparable risk for non\u2010HCC<\/jats:styled-content> liver\u2010related events (HR<\/jats:styled-content> = 1.02; 95% CI<\/jats:styled-content> = 0.66\u20101.59; P<\/jats:italic>\u00a0=\u00a0.93), compared with the inactive CHB<\/jats:styled-content> group. Among patients with cirrhosis, the NA<\/jats:styled-content> group showed a significantly lower risk of death (HR<\/jats:styled-content> = 0.31; 95% CI<\/jats:styled-content> = 0.097\u20100.998; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.05) and non\u2010HCC<\/jats:styled-content> liver\u2010related events (HR<\/jats:styled-content> = 0.51; 95% CI<\/jats:styled-content> = 0.31\u20100.83; P<\/jats:italic>\u00a0<\u00a0.01), but a slightly higher risk of HCC<\/jats:styled-content> (HR<\/jats:styled-content> = 2.39; 95% CI<\/jats:styled-content> = 0.85\u20106.75; P<\/jats:italic>\u00a0=\u00a0.09), compared to the inactive CHB<\/jats:styled-content> group. The overall survival of untreated patients with inactive CHB<\/jats:styled-content> and of CHB<\/jats:styled-content> patients achieving viral suppression with NA<\/jats:styled-content> was comparable. However, NA<\/jats:styled-content> treatment of cirrhotic patients was significantly associated with longer overall survival and lower risk of liver\u2010related events.<\/jats:p>","DOI":"10.1111\/jvh.12927","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T11:04:23Z","timestamp":1525863863000},"page":"1161-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of overall survival between antiviral\u2010induced viral suppression and inactive phase chronic hepatitis B patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-5357","authenticated-orcid":false,"given":"Y. Y.","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Chung\u2010Ang University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-2080","authenticated-orcid":false,"given":"J.\u2010H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Y.","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-7773","authenticated-orcid":false,"given":"Y. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010H.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12818"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14964-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.08.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26301"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23785"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26180"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033364"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.5896"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306409"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13253"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12224"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.22.1.18"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28916"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit768"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.12.6163"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80140-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.08.045"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.08.021"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.09.50"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9040075"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.07.012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.12927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.12927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:44:02Z","timestamp":1695019442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.12927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jvh.12927"],"URL":"https:\/\/doi.org\/10.1111\/jvh.12927","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,24]]},"assertion":[{"value":"2018-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}