{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:04:48Z","timestamp":1785168288247,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["GS\u2010US\u2010174\u20100208"],"award-info":[{"award-number":["GS\u2010US\u2010174\u20100208"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Summary<\/jats:title>Entecavir 0.5\u00a0mg (ETV<\/jats:styled-content>) is widely used among treatment\u2010na\u00efve chronic hepatitis B (CHB<\/jats:styled-content>) patients. However, 10%\u201030% of patients show partial virologic response (PVR<\/jats:styled-content>) to the drug. If the hepatitis B virus (HBV<\/jats:styled-content>) continues to replicate, the underlying liver disease may progress. Herein, we compared the efficacy of switching to tenofovir disoproxil fumarate (TDF<\/jats:styled-content>) with that of continuing ETV<\/jats:styled-content> in CHB<\/jats:styled-content> patients with PVR<\/jats:styled-content> to ETV<\/jats:styled-content>. This was an open\u2010label randomized controlled trial including CHB<\/jats:styled-content> patients who had been receiving 0.5\u00a0mg of ETV<\/jats:styled-content> for >12\u00a0months, but who still had detectable HBV DNA<\/jats:styled-content> levels of >60\u00a0IU<\/jats:styled-content>\/mL<\/jats:styled-content> without known resistance to ETV<\/jats:styled-content>. Sixty patients were enrolled and 45 qualified for the study: Twenty\u2010two patients were randomly assigned into the TDF<\/jats:styled-content> group and 23 into the ETV<\/jats:styled-content> group. After 12\u00a0months of treatment, the virologic response rate (HBV DNA<\/jats:styled-content> <20\u00a0IU<\/jats:styled-content>\/mL<\/jats:styled-content>) was significantly higher in the TDF<\/jats:styled-content> group than in the ETV<\/jats:styled-content> group, as measured using per\u2010protocol analysis (55% vs 20%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.022) and intention\u2010to\u2010treat analysis (50% vs 17.4%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.020). The reduction in HBV DNA<\/jats:styled-content> was greater (\u22121.13 vs \u22120.67 log10<\/jats:sub> IU<\/jats:styled-content>\/mL<\/jats:styled-content>; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.024), and the mean HBV DNA<\/jats:styled-content> level was lower (1.54 vs 2.01 log10<\/jats:sub> IU<\/jats:styled-content>\/mL<\/jats:styled-content>; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.011) in the TDF<\/jats:styled-content> group than in the ETV<\/jats:styled-content> group. In conclusion, to achieve optimal response in CHB<\/jats:styled-content> patients with PVR<\/jats:styled-content> to ETV<\/jats:styled-content>, switching to TDF<\/jats:styled-content> would be a better strategy than continuing ETV<\/jats:styled-content>. Appropriate modification of therapy would further improve the outcome of chronic HBV<\/jats:styled-content> infection.<\/jats:p>","DOI":"10.1111\/jvh.12934","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T18:59:41Z","timestamp":1526583581000},"page":"1321-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Switching to tenofovir vs continuing entecavir for hepatitis B virus with partial virologic response to entecavir: a randomized controlled trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-2754","authenticated-orcid":false,"given":"H. J.","family":"Yim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Korea University Ansan Hospital Ansan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonbuk National University Hospital Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Ansan Hospital Ansan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. K.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Ansan Hospital Ansan South Korea"},{"name":"Department of Internal Medicine Gachon University Gil Hospital Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Guro Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. S.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Anam Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Yeon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Guro Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Uijeongbu St. Mary\u2019s Hospital, The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konkuk University Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Anam Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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