{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:28Z","timestamp":1740126148852,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105\u20102628\u2010B\u2010075\u2010006\u2010MY2"],"award-info":[{"award-number":["MOST 105\u20102628\u2010B\u2010075\u2010006\u2010MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Summary<\/jats:title>The risk of renal events in HB<\/jats:styled-content>sAg\u2010positive cancer patients receiving tenofovir disoproxil fumarate (TDF<\/jats:styled-content>) or entecavir (ETV<\/jats:styled-content>) antiviral prophylaxis during chemotherapy has not been evaluated. This study aimed to evaluate the renal safety of TDF<\/jats:styled-content> and ETV<\/jats:styled-content> during chemotherapy. Consecutive, 219 HB<\/jats:styled-content>sAg\u2010positive cancer patients treated with TDF<\/jats:styled-content> (n\u00a0=\u00a0106) or ETV<\/jats:styled-content> (n\u00a0=\u00a0113) for antiviral prophylaxis during chemotherapy with baseline serum creatinine (SC<\/jats:styled-content>r) <1.2\u00a0mg\/dL were retrospectively enrolled. Serial SC<\/jats:styled-content>r levels and estimated glomerular filtration rate (eGFR<\/jats:styled-content>) were monitored. The incidence of acute kidney injury (AKI<\/jats:styled-content>) during antiviral prophylaxis was 33% and 38.9% in TDF<\/jats:styled-content> and ETV<\/jats:styled-content> groups, respectively (P<\/jats:italic>\u00a0=\u00a00.441), while the incidence of sustained kidney injury was 11.3% and 11.5%, respectively (P<\/jats:italic>\u00a0=\u00a01.000). By multivariate analysis, diuretics use (hazard ratio (HR<\/jats:styled-content>)\u00a0=\u00a02.011, P<\/jats:italic>\u00a0=\u00a00.042) and serum albumin levels (HR<\/jats:styled-content>\u00a0=\u00a00.441, P<\/jats:italic>\u00a0=\u00a00.001) were independent predictors of AKI<\/jats:styled-content>; serum albumin levels (HR<\/jats:styled-content>\u00a0=\u00a00.252, P<\/jats:italic>\u00a0=\u00a00.002) was the only factor associated with sustained kidney injury; age (HR<\/jats:styled-content>\u00a0=\u00a02.752, P<\/jats:italic>\u00a0<\u00a00.001), baseline SC<\/jats:styled-content>r levels (HR<\/jats:styled-content>\u00a0=\u00a03.386, P<\/jats:italic>\u00a0<\u00a00.001), and serum albumin levels (HR<\/jats:styled-content>\u00a0=\u00a00.437, P<\/jats:italic>\u00a0=\u00a00.001) were factors associated with a new eGFR<\/jats:styled-content> <60\u00a0mL\/min. 34.9% of patients in TDF<\/jats:styled-content> group and 35.4% in ETV<\/jats:styled-content> group had deteriorated chronic kidney disease (CKD<\/jats:styled-content>) stage at the end of follow\u2010up, respectively. There were no significant differences in the risk of renal events or CKD<\/jats:styled-content> stage migration between TDF<\/jats:styled-content> and ETV<\/jats:styled-content> groups. Renal events may develop in about one\u2010third of HB<\/jats:styled-content>sAg\u2010positive cancer patients undergoing chemotherapy. The risk of renal function impairment was comparable between patients treated with TDF<\/jats:styled-content> and ETV<\/jats:styled-content> antiviral prophylaxis.<\/jats:p>","DOI":"10.1111\/jvh.12984","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T07:57:17Z","timestamp":1534751837000},"page":"1599-1607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk of renal events during tenofovir disoproxil fumarate and entecavir antiviral prophylaxis in HBsAg\u2010positive cancer patients undergoing chemotherapy"],"prefix":"10.1111","volume":"25","author":[{"given":"I\u2010Cheng","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee","family":"Chao","sequence":"additional","affiliation":[{"name":"Cancer Center Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Pin","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keng\u2010Hsin","family":"Lan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Pharmacology National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chih","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei 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