{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:48:01Z","timestamp":1787060881199,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Summary<\/jats:title>\n \n The prevalence of chronic hepatitis C virus (\n HCV<\/jats:styled-content>\n ) and the presence of human pegivirus 2 (\n HP<\/jats:styled-content>\n gV\u20102) have not been examined in Cameroon, although\n HCV<\/jats:styled-content>\n has been associated with\n HP<\/jats:styled-content>\n gV\u20102 infections previously. Herein we aimed to characterize the burden and genetic diversity of\n HCV<\/jats:styled-content>\n and the presence of\n HP<\/jats:styled-content>\n gV\u20102 in Cameroon. Retrospective plasma specimens collected from N\u00a0=\u00a012\u00a0369 consenting subjects in South Cameroon from 2013 to 2016 were included in the study. The majority (97.1%) of participants were patients seeking health care. All specimens were screened for\n HCV<\/jats:styled-content>\n using the Abbott RealTi\n m<\/jats:italic>\n e\n HCV<\/jats:styled-content>\n viral load assay and positive specimens with remaining volume were also screened for\n HP<\/jats:styled-content>\n gV\u20102 antibodies on the Abbott\n ARCHITECT<\/jats:styled-content>\n instrument, followed by molecular characterization. Overall,\n HCV RNA<\/jats:styled-content>\n was detected in 305 (2.47%; 95%\n CI<\/jats:styled-content>\n : 2.21%\u20102.75%) specimens. Notably, the prevalence of\n HCV RNA<\/jats:styled-content>\n was 9.09% amongst participants over age 40 and 3.81% amongst males. Phylogenetic classification of N\u00a0=\u00a0103\n HCV<\/jats:styled-content>\n sequences identified genotypes 1 (19.4%), 2 (15.5%) and 4 (65.1%) within the study cohort. Amongst\n HCV RNA<\/jats:styled-content>\n \u2010positive specimens, N\u00a0=\u00a028 (10.6%; 95%\n CI<\/jats:styled-content>\n : 7.44%\u201014.90%) specimens also had detectable\n HP<\/jats:styled-content>\n gV\u20102 antibodies. Of these, N\u00a0=\u00a02 viremic\n HP<\/jats:styled-content>\n gV\u20102 infections were confirmed by sequencing and shared 93\u201094 median % identity with strains found on other continents. This is the first study to determine the prevalence of chronic\n HCV<\/jats:styled-content>\n in Cameroon, and the discovery of\n HP<\/jats:styled-content>\n gV\u20102 in this study cohort expands the geography of\n HP<\/jats:styled-content>\n gV\u20102 to the African continent, indicating a widespread distribution exists.\n <\/jats:p>","DOI":"10.1111\/jvh.12996","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T22:33:12Z","timestamp":1536186792000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hepatitis C virus surveillance and identification of human pegivirus 2 in a large Cameroonian cohort"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8815-8651","authenticated-orcid":false,"given":"Mary A.","family":"Rodgers","sequence":"first","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Holzmayer","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vallari","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Olivo","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn","family":"Forberg","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Fuhrman","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Coller","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bih","family":"Awazi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules Bertrand","family":"Kenmegne Sidje","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Berg","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Mbanya","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"University of Bamenda Bamenda Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicaise","family":"Ndembi","sequence":"additional","affiliation":[{"name":"Institute of Human Virology Abuja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin A.","family":"Cloherty","sequence":"additional","affiliation":[{"name":"Abbott Laboratories Abbott Park Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.02.006"},{"key":"e_1_2_7_3_1","volume-title":"Global Hepatitis Report, 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MDH.HIV Prevalence in Cameroon: Findings from the 2011 DHS\u2010MICS. 2012."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10473"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.52.98"},{"key":"e_1_2_7_33_1","first-page":"949","article-title":"Incidence de la lomidinisation sur la re\u2032gression de la trypanosomiase au Cameroun franc\u00b8ais","volume":"13","author":"Beaudiment RL","year":"1953","journal-title":"Med Trop"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06967-7"},{"key":"e_1_2_7_35_1","first-page":"473","article-title":"La maladie du sommeil au Cameroun en janvier","volume":"22","author":"Jamot E","year":"1929","journal-title":"Bull Soc Pathol Exot"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1954.11685622"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/088922203771881158"}],"container-title":["Journal of Viral 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