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Because of these, we report the occurrence of severe infections after starting<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>regimens in<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010coinfected patients. Individuals included in the<jats:styled-content style=\"fixed-case\">HEPAVIR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02057003) cohort were selected if they had received all\u2010oral<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>combinations. A retrospective review of clinical events registered between the start of<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s and 12\u00a0months after<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>12 was carried out. Overall, 38 (4.5%) of 848 patients presented infections. The incidence (95% confidence interval) of infections was 4.6 (3.3\u20106.3) cases per 100 person\u2010years. The median (Q1\u2010Q3) time to the infection since baseline was 23 (7.3\u201033) weeks. Five (13%) of the patients with infections died; four of them had cirrhosis. The frequency of previous<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>was 21 (54%) for patients with infections and 324 (40%) for those without infections (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.084). The median (Q1\u2010Q3) nadir<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 cell count of individuals with and without infections was 75 (53\u2010178) and 144 (67\u2010255) cells\/\u03bcL, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047). Immunodepression\u2010associated infections were observed in 9 (1.1%) patients. All of them had suppressed<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>replication with antiretroviral therapy. In conclusion, severe infections are relatively common among<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010coinfected patients receiving all\u2010oral<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>combinations. Some unusual reactivations of latent infections in patients with suppressed<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>replication seem to be temporally linked with<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>use.<\/jats:p>","DOI":"10.1111\/jvh.13003","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T20:24:01Z","timestamp":1536611041000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early emergence of opportunistic infections after starting direct\u2010acting antiviral drugs in HIV\/HCV\u2010coinfected patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-790X","authenticated-orcid":false,"given":"Juan","family":"Mac\u00edas","sequence":"first","affiliation":[{"name":"Infectious Diseases and Microbiology Unit Hospital Universitario de Valme Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"T\u00e9llez","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Microbiology Unit Hospital Universitario de Puerto Real Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de la Provincia de C\u00e1diz (INiBICA) Cadiz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rivero\u2010Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Instituto Maimonides de Investigaci\u00f3n Biomedica de C\u00f3rdoba (IMIBIC) Hospital Universitario Reina Sofia Cordoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Palacios","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Microbiology and Preventive Medicine Unit Hospital Universitario Virgen de la Victoria Malaga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Morano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Universitario Alvaro Cunqueiro Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Merino","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Juan Ram\u00f3n Jim\u00e9nez Huelva Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Collado","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Torrec\u00e1rdenas Almeria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Garc\u00eda\u2010Fraile","sequence":"additional","affiliation":[{"name":"Infectious Diseases\u2010Internal Medicine Service Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Omar","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital de Jaen Jaen Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-0296","authenticated-orcid":false,"given":"Juan A.","family":"Pineda","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Microbiology Unit Hospital Universitario de Valme Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of the HEPAVIR, GEHEP and RIS\u2010HEP07 study groups","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit103"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/cid\/ciw809","article-title":"Hepatitis C infection and the risk of non\u2010liver\u2010related morbidity and mortality in HIV\u2010positive persons in the Swiss HIV Cohort Study","volume":"64","author":"Kovari H","year":"2017","journal-title":"Clin Infect Dis"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315722"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402869"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306218"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402454"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000705"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15284336.2017.1330801"},{"key":"e_1_2_7_10_1","unstructured":"Mac\u00edasJ Morano\u2010AmadoLE Cuenca\u2010L\u00f3pezF et\u00a0al.High efficacy of IFN\u2010free anti\u2010HCV regimens for individuals on opiate agonist therapy. 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