{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:41:00Z","timestamp":1768322460103,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2016\u2010I2M\u20103\u2010024"],"award-info":[{"award-number":["2016\u2010I2M\u20103\u2010024"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic hepatitis B virus (HBV) infection is influenced by both viral and host factors. In genome\u2010wide association studies, the human leucocyte antigen HLA\u2010DPA1 and related polymorphism rs3077 were found to be associated with susceptibility to and spontaneous clearance of HBV infection. Here, we evaluated the association between <jats:italic>HLA\u2010DPA1<\/jats:italic> mRNA expression and the risk of HBV infection. HLA\u2010DPA1 and rs3077 polymorphisms were investigated in 169 patients with chronic HBV and 217 healthy controls (HCs) from Sichuan Han blood donors using sequence\u2010based typing and meta\u2010analysis for HLA\u2010DPA1 alleles. <jats:italic>HLA\u2010DPA1<\/jats:italic> mRNA levels were measured by real\u2010time polymerase chain reaction. The results showed that HLA\u2010DPA1 and rs3077 were associated with HBV infection in the Sichuan population. Rs3077T and DPA1*01:03 played protective roles in HBV infection, and rs3077C and DPA1*02:02 increased susceptibility to HBV infection. We found that the <jats:italic>HLA\u2010DPA1<\/jats:italic> mRNA expression was decreased in the CHB group; in particular, the 3077CT, 3077TT, DPA1*01:03 and DPA1*02:01 alleles showed a significant decrease. Our results demonstrated, for the first time, that expression of HLA\u2010DPA1 alleles and rs3077 affected the risk of HBV infection. Genotypes with lower <jats:italic>HLA\u2010DPA1<\/jats:italic> expression had a greater susceptibility to HBV infection. Thus, further independent studies are needed to strengthen the associations of these polymorphisms with susceptibility to and clearance of HBV infection in Chinese populations.<\/jats:p>","DOI":"10.1111\/jvh.13012","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T12:38:05Z","timestamp":1538224685000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship between <i>HLA\u2010DPA1<\/i> mRNA expression and susceptibility to hepatitis B"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-7951","authenticated-orcid":false,"given":"Guojin","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion CAMS &amp; PUMC  Chengdu China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University)  Ministry of Education   Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Deyang People's Hospital  Deyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianfu New District People's Hospital  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion CAMS &amp; PUMC  Chengdu China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ji","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion CAMS &amp; PUMC  Chengdu China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion CAMS &amp; PUMC  Chengdu China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion CAMS &amp; PUMC  Chengdu China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiong","family":"Qian","sequence":"additional","affiliation":[{"name":"Deyang Central Blood Station  Deyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion CAMS &amp; PUMC  Chengdu China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Blood Transfusion Research Center Institute of Blood Transfusion CAMS &amp; PUMC  Chengdu China"},{"name":"Key Laboratory of Transfusion Adverse Reactions CAMS  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4346(96)82012-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.08.048"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61412-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12220"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27406"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.348"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq154"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024221"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00406-12"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066920"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.03.034"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24767"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.19747"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032605"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.11"},{"issue":"29","key":"e_1_2_8_18_1","first-page":"368","article-title":"Establishment of a preliminary real\u2010time quantitative RT\u2010PCR and nucleic acid test method to detect HBV based on nationalistic characteristics","volume":"04","author":"Liu X","year":"2016","journal-title":"Chin J Blood Transf [In Chinese]"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.10.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1984.tb00050.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01458.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086449"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14933"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.486"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09914"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.13012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:58:11Z","timestamp":1694656691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/jvh.13012"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13012","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,25]]},"assertion":[{"value":"2017-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}