{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:19Z","timestamp":1787015659834,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00P3_133703"],"award-info":[{"award-number":["PP00P3_133703"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Acute liver failure (\n                    <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>\n                    ) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (\n                    <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\n                    ) that carries a high mortality rate. The occurrence of a life\u2010threatening condition upon infection with a prevalent virus in individuals without known risk factors is suggestive of pathogen\u2010specific immune dysregulation. In the absence of established differences in\n                    <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\n                    virulence, we hypothesized that\n                    <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>\n                    upon primary infection with\n                    <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\n                    could be due to rare deleterious variants in the human genome. To search for such variants, we performed exome sequencing in 21 previously healthy adults who required liver transplantation upon fulminant\n                    <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\n                    infection and 172 controls that were positive for anti\u2010\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    c and anti\u2010\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    s but had no clinical history of jaundice or liver disease. After a series of hypothesis\u2010driven filtering steps, we searched for putatively pathogenic variants that were significantly associated with case\u2010control status. We did not find any causal variant or gene, a result that does not support the hypothesis of a shared monogenic basis for human susceptibility to\n                    <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\n                    \u2010related\n                    <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>\n                    in adults. This study represents a first attempt at deciphering the human genetic contribution to the most severe clinical presentation of acute\n                    <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\n                    infection in previously healthy individuals.\n                  <\/jats:p>","DOI":"10.1111\/jvh.13019","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T07:41:31Z","timestamp":1539416491000},"page":"271-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients"],"prefix":"10.1111","volume":"26","author":[{"given":"Samira","family":"Asgari","sequence":"first","affiliation":[{"name":"School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  Lausanne Switzerland"},{"name":"Swiss Institute of 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