{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:30:02Z","timestamp":1784302202482,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["15275"],"award-info":[{"award-number":["15275"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Worldwide, hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) occurs mainly in Asian patients with hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) infection. This study aimed to decipher the environmental and virological factors associated with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> occurrence and validate risk scoring systems in a French multicentre prospective cohort of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> cirrhotic patients. Patients with biopsy\u2010proven Child\u2010Pugh A viral cirrhosis included in the <jats:styled-content style=\"fixed-case\">ANRS CO<\/jats:styled-content>12 CirVir cohort who were <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg(+) without hepatitis C coinfection were selected for: (a) interview through a standardized questionnaire reporting coffee consumption and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> familial history; (b) <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg quantification using baseline and sequential 2\u2010year frozen sera; (c) baseline <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> genotype determination; and (d) assessment of risk factors and applicability of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> risk scores (Kaplan\u2010Meier analysis, Cox models). Among 317 patients studied (261 men, median age 53\u00a0years, past or ongoing antiviral treatment 93.3% and baseline detectable <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> in 88 patients), the baseline and 2\u2010year median <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg levels were 810 and 463\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively. After a median follow\u2010up of 65.2 months, 27 <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> cases were diagnosed (annual incidence: 1.6%). Three factors were independently associated with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> occurrence: age\u00a0&gt;\u00a050\u00a0years, platelets\u00a0\u2264\u00a0150\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup> and body mass index\u00a0\u2265\u00a030\u00a0kg\/m<jats:sup>2<\/jats:sup>. Two out of five risk scores were validated, and the most accurate was <jats:styled-content style=\"fixed-case\">PAGE<\/jats:styled-content>\u2010B at 1\u00a0year. Moreover, <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> in patients without maintained virological suppression seems more aggressive and less accessible to curative treatment. In conclusion, in French patients with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> cirrhosis mostly virally suppressed, independent <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> risk factors were host\u2010related (age, obesity) or linked to the severity of cirrhosis (thrombopenia), and the European <jats:styled-content style=\"fixed-case\">PAGE<\/jats:styled-content>\u2010B score was the most accurate risk score.<\/jats:p>","DOI":"10.1111\/jvh.13029","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T14:38:29Z","timestamp":1540996709000},"page":"384-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Non\u2010virological factors are drivers of hepatocellular carcinoma in virosuppressed hepatitis B cirrhosis: Results of <scp>ANRS CO<\/scp>12 CirVir cohort"],"prefix":"10.1111","volume":"26","author":[{"given":"Segolene","family":"Brichler","sequence":"first","affiliation":[{"name":"AP\u2010HP H\u00f4pital Avicenne Microbiologie Clinique  Bobigny France"},{"name":"Universit\u00e9 Paris 13  Bobigny France"},{"name":"INSERM U955 Universit\u00e9 Paris\u2010Est  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Nahon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 13  Bobigny France"},{"name":"AP\u2010HP H\u00f4pital Jean\u2010Verdier H\u00e9patologie  Bondy France"},{"name":"INSERM U1162 Universit\u00e9 Paris 5  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Zoulim","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon  H\u00e9patologie, Lyon France"},{"name":"INSERM U1052 Universit\u00e9 de Lyon  Lyon 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