{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:33:21Z","timestamp":1790087601634,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["No. Z161100004916105"],"award-info":[{"award-number":["No. Z161100004916105"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["No.XXX 0104"],"award-info":[{"award-number":["No.XXX 0104"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>It is unknown whether dynamic changes of liver stiffness measurement (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>) can predict the reversibility of fibrosis. Therefore, we evaluated the utility of <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> changes in predicting histological changes of fibrosis in patients with chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) on antiviral therapy. In a prospective cohort of <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> patients treated with entecavir, virological measurement and biochemical measurement along with <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> were measured at baseline and every 6\u00a0months. Liver biopsies were conducted at baseline and month 18 of treatment. Fibrosis regression was defined by the following two criteria: (a) Ishak score decrease \u22651 stage, (b) Ishak score decrease \u22651 stage or predominantly regressive by post\u2010treatment PIR classification. The dynamic changes of <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> and its predictive value for histological reversibility were evaluated with piecewise linear mixed\u2010effects model and <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis. We found that at month 18 of antiviral therapy, liver fibrosis was reserved in 86 of 212 (40.6%) <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> patients by Ishak reversal criterion. Overall, a decline in <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> was associated with attenuation of Ishak score. The rate of <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> decline in the first 6\u00a0months was significantly faster in patients with fibrosis reversal (\u0394<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>%<jats:sub>Ishak<\/jats:sub>\u00a0=\u00a0\u22122.19%\/month, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0025; \u0394<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>%<jats:sub>Ishak\/<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>PIR<\/jats:sub><\/jats:styled-content>\u00a0=\u00a0\u22122.56%\/month, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0004). The predictive model based on baseline <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 and Ishak score as well as baseline <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PLT<\/jats:styled-content>, albumin and their changes during the first 6\u00a0months could predict histological reversal (<jats:styled-content style=\"fixed-case\">AUROC<jats:sub>Ishak<\/jats:sub><\/jats:styled-content>\u00a0=\u00a00.74, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.67\u20100.80; <jats:styled-content style=\"fixed-case\">AUROC<jats:sub>Ishak\/PIR<\/jats:sub><\/jats:styled-content>\u00a0=\u00a00.81, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.74\u20100.87). We conclude that in <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> patients, changes in <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> during the first 6\u00a0months of entecavir therapy can predict histological reversibility of liver fibrosis at month 18 of antiviral therapy.<\/jats:p>","DOI":"10.1111\/jvh.13058","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T12:54:21Z","timestamp":1547038461000},"page":"576-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Early steep decline of liver stiffness predicts histological reversal of fibrosis in chronic hepatitis B patients treated with entecavir"],"prefix":"10.1111","volume":"26","author":[{"given":"Yuanyuan","family":"Kong","sequence":"first","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yameng","family":"Sun","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Wu","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis  Beijing China"},{"name":"National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongpeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Piao","sequence":"additional","affiliation":[{"name":"Development of Infectious Diseases Affiliated Hospital of Yanbian University  Yanji 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