{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:08:20Z","timestamp":1762459700818,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Summary<\/jats:title>The role of condomless anal intercourse (CAI<\/jats:styled-content>) as a driver for the epidemic of hepatitis C in MSM<\/jats:styled-content> is still debated. Timely access to direct\u2010acting antivirals (DAA<\/jats:styled-content>) could represent an essential strategy to tackle this. Case notes of MSM<\/jats:styled-content> diagnosed with acute hepatitis C (AHC<\/jats:styled-content>) between July 2016 and June 2017 in a sexual health clinic in London were included. Behavioural data on sexual practices and STI<\/jats:styled-content> monitoring in the 6\u00a0months prior to AHC<\/jats:styled-content> diagnosis were collected. DAA<\/jats:styled-content> routes of access and timing from AHC<\/jats:styled-content> diagnosis to start of treatment were analysed. A total of 60 individuals were enrolled (median age 39\u00a0years, IQR<\/jats:styled-content>\u00a0=\u00a033\u201046, 62% HIV<\/jats:styled-content> co\u2010infected, 72% genotype 1a). CAI<\/jats:styled-content> was reported by 97%, drug use prior to or during sex by 73%; 46% was diagnosed with a rectal STI<\/jats:styled-content> and 29% with syphilis. About 37% did not report any HCV<\/jats:styled-content> risk factors other than condomless anal sex. About 36% had a new rectal STI<\/jats:styled-content> in the 6\u00a0months following AHC<\/jats:styled-content>. About 82% accessed DAA<\/jats:styled-content> treatment and median time from AHC<\/jats:styled-content> to DAA<\/jats:styled-content> start was 278\u00a0days for those following the NHS<\/jats:styled-content> standard of care route, 132\u00a0days for those accessing DAA<\/jats:styled-content> via participation in trials and 114 for those who had self\u2010sourced DAA<\/jats:styled-content> online (P\u00a0<\u00a0<\/jats:italic>0.0011)<\/jats:italic>. SVR<\/jats:styled-content>12 was achieved in 100% of the patients who received DAA<\/jats:styled-content> treatment.In conclusion, CAI<\/jats:styled-content> is a significant risk factor for HCV<\/jats:styled-content> acquisition in MSM<\/jats:styled-content>, irrespective of their HIV<\/jats:styled-content> status. Rapid and wider access to treatment with DAA<\/jats:styled-content> could represent a powerful strategy to reduce onward transmission and risk of reinfection in MSM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.13066","type":"journal-article","created":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T06:28:23Z","timestamp":1547965703000},"page":"627-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High rates of unprotected anal sex and use of generic direct\u2010acting antivirals in a cohort of MSM<\/scp> with acute HCV<\/scp> infection"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-2748","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Girometti","sequence":"first","affiliation":[{"name":"56 Dean Street, Chelsea & Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Devitt","sequence":"additional","affiliation":[{"name":"56 Dean Street, Chelsea & Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Phillips","sequence":"additional","affiliation":[{"name":"56 Dean Street, Chelsea & Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Nelson","sequence":"additional","affiliation":[{"name":"Chelsea & Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Whitlock","sequence":"additional","affiliation":[{"name":"56 Dean Street, Chelsea & Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2007.027334"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32835c2120"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833c11a5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283471cce"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050566"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH16141"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000528"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv115"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/QAD.0b013e328343443b","article-title":"Acute hepatitis C in HIV\u2010infected individuals\u2013recommendations from the NEAT consensus conference","volume":"25","author":"The European AIDS Treatment Network (NEAT) Acute Hepatitis C Infection Consensus Panel","year":"2011","journal-title":"AIDS"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ948"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052505"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2017-053315"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32836381cc"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.09.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001789"},{"volume-title":"25th Conference on Retroviruses and Opportunistic Infections","author":"Ingiliz P","key":"e_1_2_8_19_1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12859"},{"key":"e_1_2_8_21_1","unstructured":"World Health Organization.Combating hepatitis B and C to reach elimination by 2030: advocacy brief. 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