{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:50:20Z","timestamp":1758120620442,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Summary<\/jats:title>The aims of the present study were to evaluate the efficacy and tolerability of ledipasvir\/sofosbuvir (LDV<\/jats:styled-content>\/SOF<\/jats:styled-content>) with or without ribavirin in the treatment of chronic hepatitis C (CHC<\/jats:styled-content>) in patients with advanced liver disease and to analyse whether the use of LDV<\/jats:styled-content>\/SOF<\/jats:styled-content> treatment is associated with a new occurrence of hepatocellular carcinoma (HCC<\/jats:styled-content>) during and after LDV<\/jats:styled-content>\/SOF<\/jats:styled-content> treatment. The Turkish Early Access Program provided LDV<\/jats:styled-content>\/SOF<\/jats:styled-content> treatment to a total of 200 eligible CHC<\/jats:styled-content> patients with advanced liver disease. The median follow\u2010up period was 22\u00a0months. All patients were Caucasian, 84% were infected with genotype 1b, and 24% had a liver transplantation before treatment. The sustained virological response (SVR<\/jats:styled-content>12) was 86.0% with ITT<\/jats:styled-content> analysis. SVR<\/jats:styled-content>12 was similar among patients with Child\u2010Pugh classes A, B and C disease and transplant recipients. From baseline to SVR<\/jats:styled-content>12, serum ALT<\/jats:styled-content> level and MELD<\/jats:styled-content> score were significantly improved (P<\/jats:italic>\u00a0<\u00a00.001). LDV<\/jats:styled-content>\/SOF<\/jats:styled-content> treatment was generally well tolerated. Only one patient developed a new diagnosed HCC<\/jats:styled-content>. Seventeen of the 35 patients, who had a history of previous HCC<\/jats:styled-content>, developed HCC<\/jats:styled-content> recurrence during the LDV<\/jats:styled-content>\/SOF<\/jats:styled-content> treatment or by a median follow\u2010up of 6\u00a0months after treatment. HCC<\/jats:styled-content> recurrence was less commonly observed in patients who received curative treatment for HCC<\/jats:styled-content> compared with those patients who received noncurative treatment (P<\/jats:italic>\u00a0=\u00a00.007). In conclusion, LDV<\/jats:styled-content>\/SOF<\/jats:styled-content> with or without ribavirin is an effective and tolerable treatment in CHC<\/jats:styled-content> patients with advanced liver disease. Eradication is associated with improvements in liver function and a reduced risk of developing a new occurrence of HCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jvh.13075","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T09:28:58Z","timestamp":1549877338000},"page":"666-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low recurrence rate of hepatocellular carcinoma following ledipasvir and sofosbuvir treatment in a real\u2010world chronic hepatitis C patients cohort"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-5472","authenticated-orcid":false,"given":"Ramazan","family":"Idilman","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ankara University School of Medicine Ankara 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